Results 51 to 60 of about 2,123,608 (238)

Improving the competitiveness of economic entities of the services sector

Ученые записки Российской академии предпринимательства, 2021
Priority development of the service sector observed in the last decades, quantitative and qualitative growth of this sector contributes to the transformation of competition into an integral part of economic relations.
M. Yu. Belyakova, N. V. Zhuravleva, N. Y. Ivanova   +2 more
doaj  

Specifics of leadership in tourism with the aim of successful business processes [PDF]

Megatrend Revija, 2020
Tourism in the new century is becoming a major economic force. Because of the specific nature of the business that includes travelling and staying outside the place of residence, i.e. specific services organized tourist industry significantly participate
Ilić Biljana, Stefanović Vidoje, Žikić Srđan   +2 more
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

On the Need for a General REST-Security Framework

Future Internet, 2019
Contemporary software is inherently distributed. The principles guiding the design of such software have been mainly manifested by the service-oriented architecture (SOA) concept.
Luigi Lo Iacono, Hoai Viet Nguyen, Peter Leo Gorski   +2 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

One size does not fit all: a qualitative exploration of the experiences of Canadian youth with neurodevelopmental disabilities during the COVID-19 pandemic

Frontiers in Public Health
IntroductionYouth with neurodevelopmental disabilities (NDD) were disproportionately impacted by the COVID-19 pandemic due to health and socioeconomic factors and system level disruption of essential supports.
Brittany Finlay, Ashish Seth, Genevieve Currie, Genevieve Currie, Christiane Roth, Anne Hudon, Matthew Hunt, Lucyna M. Lach, David B. Nicholas, Keiko Shikako, Jennifer D. Zwicker, Jennifer D. Zwicker   +11 more
doaj   +1 more source

Model Application of Accounting Information Systems of Spare Parts Sales and Purchase on Car Service Company

ComTech, 2015
The purpose of this research is to analyze accounting information systems of sales and purchases of spare parts in general car service companies and to identify the problems encountered and the needs of necessary information.
Lianawati Christian
doaj   +1 more source

Service Systems and Service Innovation: Two Pillars of Service Science

Procedia Computer Science, 2016
AbstractService science is perceived as a multidisciplinary approach with the service system as its most important element. The services we use are provided through a certain service system, whereas service system has a specific structure and creates value through defined interactions between its entities, as well as through interactions with external ...
Stoshikj, Marina, Kryvinska, Natalia, Strauss, Christine   +2 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source