Results 181 to 190 of about 149,554 (331)

Strategic Timing of Gene Silencing: Cellular Kinetics‐Based Administration of siRNA for Optimized Photothermal Cancer Treatment

open access: yesAdvanced Science, EarlyView.
Coordinating therapy with gene expression kinetics emerges as a key strategy for maximizing nanomedicine efficacy in aggressive cancers. A hybrid nanocarrier delivering HSP70‐targeting siRNA demonstrates this chronotherapeutic principle through systematic cellular profiling.
Tianliang Fang   +6 more
wiley   +1 more source

PDZK1 Protects Against RPE Senescence by Targeting the 14‐3‐3ε‐mTOR Axis to Attenuate Early Diabetic Retinopathy

open access: yesAdvanced Science, EarlyView.
PDZK1 down‐regulation couples high‐glucose stress to RPE senescence via a PDZK1–14‐3‐3ε–mTOR axis. Restoring PDZK1 or clearing senescent cells rescues retinal homeostasis and mitigates early diabetic retinopathy (DR). This study provides direct evidence linking RPE cell senescence to DR pathogenesis and reveals a promising therapeutic strategy for DR ...
Jian Zhao   +6 more
wiley   +1 more source

A lightweight countermeasure to cope with flooding attacks against session initiation protocol [PDF]

open access: green, 2013
Intesab Hussain   +3 more
openalex   +1 more source

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

open access: yesAdvanced Science, EarlyView.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato   +5 more
wiley   +1 more source

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

open access: yesAdvanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao   +12 more
wiley   +1 more source

Visual Outcomes Following Hyperbaric Oxygen Therapy in Acute Central Retinal Artery Occlusion Patients. [PDF]

open access: yesClin Ophthalmol
Thoongsuwan S   +9 more
europepmc   +1 more source

Multi‐Level Optical Physical Unclonable Function Based on Random Surface Scattering for Hierarchical Cryptographic Protocols

open access: yesAdvanced Science, EarlyView.
This study proposed physical unclonable function based multi‐level key space generation scheme. By exploiting speckle characteristic, a size‐controllable structure is achieved and that is suitable foundation for multiple key extraction. The flexible key space supports various specifications for advanced applications, such as hierarchical authentication
Jeong Jin Kim, Min Seong Kim, Gil Ju Lee
wiley   +1 more source

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