Results 201 to 210 of about 149,554 (331)

Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
This study demonstrates that a hydrogel with mechanical properties matching the spinal cord directs fibroblast alignment, reshaping fibrotic scars into parallel matrices. A specific fibroblast subset mediates extracellular matrix remodeling through mechanotransduction, promoting axonal regeneration and neural reconnections, revealing potential ...
Longyou Xiao   +11 more
wiley   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

open access: yesAdvanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li   +10 more
wiley   +1 more source

Light Metabolically Reprograms CD8+ T Cells to Potentiate STING‐Driven Tumor Eradication and Prevent Metastasis

open access: yesAdvanced Science, EarlyView.
Low‐level light (LLL) rejuvenates exhausted CD8+ T cells, boosting STING‐driven tumor eradication and prevents metastasis. NanoSTING@Mn enhances CD8+ T cells infiltration while LLL restores its function expanding to progenitor‐exhausted cells. These cells form central memory T cells in lymphoid organs. Intranasal nanoSTING@Mn redirects antitumor CD8+ T
Asmita Banstola   +9 more
wiley   +1 more source

Long‐Term Stable Subdural Recordings Enabled by Fibrosis‐Resistant Hydrogel‐Integrated µECoG Arrays

open access: yesAdvanced Science, EarlyView.
An adhesive hydrogel‐integrated micro‐electrocorticography (aGel‐µECoG) array is developed to ensure stable neural recordings by minimizing neuroinflammation and fibrosis during implantation. The hydrogel serves as a biological and mechanical bridge, enabling bioadhesive, reversible, anti‐fibrotic integration with brain tissue.
Lin Chen   +13 more
wiley   +1 more source

Life‐Cycle Assessment of Printed Electronic Components ‐ Case Study for Organic Electrochemical Transistors

open access: yesAdvanced Electronic Materials, EarlyView.
This tutorial introduces a practical framework for implementing early‐stage Life‐Cycle Assessment (LCA) in flexible and printed electronics. Using organic electrochemical transistors (OECTs) as a case study, the modular Process‐of‐Record and open‐access inventory provides a rich resource adaptable to a plethora of technologies in printed electronics ...
Laura Teuerle   +6 more
wiley   +1 more source

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