Results 41 to 50 of about 536,987 (307)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

PEMODELAN SET COVERING PROBLEM DALAM PENENTUAN LOKASI HALTE BUS RAPID TRANSIT (BRT) PADA KORIDOR RAJABASA-SUKARAJA DI KOTA BANDAR LAMPUNG

Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri, 2018
Bandar Lampung merupakan kota besar di Indonesia yang akan berkembang menjadi kota metropolitan. Perkembangan kota dapat dipercepat dengan pembangunan infrastruktur pelayanan publik.
Heri Wibowo, Melani Anggraini, Rio Yuri Aldino   +2 more
doaj   +1 more source

Tactical fixed job scheduling with spread-time constraints [PDF]

, 2014
We address the tactical fixed job scheduling problem with spread-time constraints. In such a problem, there are a fixed number of classes of machines and a fixed number of groups of jobs.
Zhang, Xiandong, Zhou, Shuyu, Velde, Steef van de, Chen, Bo   +3 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Binary Secretary Bird Optimization Algorithm for the Set Covering Problem

Mathematics
The Set Coverage Problem (SCP) is an important combinatorial optimization problem known to be NP-complete. The use of metaheuristics to solve the SCP includes different algorithms.
Broderick Crawford, Felipe Cisternas-Caneo, Ricardo Soto, Claudio Patricio Toledo Mac-lean, José Lara Arce, Fabián Solís-Piñones, Gino Astorga, Giovanni Giachetti   +7 more
doaj   +1 more source

Design and Optimization of Underground Logistics Transportation Networks

IEEE Access, 2019
With the burden of city transportation system becoming bigger and bigger, it is imperative to develop reliable and efficient underground logistics. The appropriate location of cargo transshipment centers in underground logistics system is selected using ...
Mu Ren, Ziwei Fan, Jianjun Wu, Li Zhou, Zhiping Du   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Novel Approach to Combinatorial Problems: Binary Growth Optimizer Algorithm

Biomimetics
The set-covering problem aims to find the smallest possible set of subsets that cover all the elements of a larger set. The difficulty of solving the set-covering problem increases as the number of elements and sets grows, making it a complex problem for
Dante Leiva, Benjamín Ramos-Tapia, Broderick Crawford, Ricardo Soto, Felipe Cisternas-Caneo   +4 more
doaj   +1 more source

On Mathematical Modelling of Automated Coverage Optimization in Wireless 5G and beyond Deployments

Applied Sciences, 2020
The need to optimize the deployment and maintenance costs for service delivery in wireless networks is an essential task for each service provider. The goal of this paper was to optimize the number of service centres (gNodeB) to cover selected customer ...
Pavel Seda, Milos Seda, Jiri Hosek
doaj   +1 more source