Results 161 to 170 of about 361,901 (315)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ostrowski's Inequality for Vector-Valued Functions and Applications

, 2001
Some Ostrowski type inequalities for vector-valued functions are obtained. Applications for operatorial inequalities and numerical approximation for the solutions of certain differential equations in Banach spaces are also ...
Cerone, Pietro, Dragomir, Sever S, Barnett, Neil S, Buşe, Constantin   +3 more
core  

Uniformly bounded set-valued Nemytskij operators acting between generalized Hölder function spaces

Open Mathematics, 2012
Matkowski Janusz, Wróbel Małgorzata
doaj   +1 more source

On the Calculus of Closed Set-Valued Functions [PDF]

Indiana University Mathematics Journal, 1974
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Maximal Dissipation and Well-Posedness of the Euler System of Gas Dynamics. [PDF]

Arch Ration Mech Anal
Feireisl E, Jüngel A, Lukáčová-Medvid'ová M.   +2 more
europepmc   +1 more source

SUBINTEGRALS OF SET-VALUED FUNCTIONS WITH SEMIANALYTIC GRAPHS [PDF]

Proceedings of the National Academy of Sciences, 1968
Halkin, H., Hendricks, E. C.
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Trace theory for parabolic boundary value problems with rough boundary conditions. [PDF]

J Evol Equ
Denk R, Roodenburg FB.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source