Results 211 to 220 of about 1,160,362 (285)

Adjoint-based PDE-constrained optimization of viscoelastic floating membrane for maximum wave power absorption. [PDF]

Struct Multidiscipl Optim
El Sayed K, Agarwal S, Metrikine A, Colomés O.   +3 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

PS Poly: A chain tracing algorithm to determine persistence length and categorize complex polymers by shape. [PDF]

PLoS One
Conley EA, Lisowski CM, Schaefer KG, Davison HC, Baguio JE, Kosztin I, King GM.   +6 more
europepmc   +1 more source

Calculus of Set Valued Functions and Control [PDF]

Indiana University Mathematics Journal, 1968
openaire   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Bayesian Image Analysis in Fourier Space. [PDF]

J Am Stat Assoc
Kornak J, Young K, Friedman E, Bakas K.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Uncertainty-Aware Training for Ophthalmic Segmentation Using MedSAM. [PDF]

Transl Vis Sci Technol
Clark CW, Kinder S, Nebbia G, Veturi YA, McNamara S, Manoharan N, Forest T, Kahook M, Mandava N, Singh P, Kalpathy-Cramer J.   +10 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cones of Noether-Lefschetz divisors and moduli spaces of hyperkähler manifolds. [PDF]

Math Ann
Barros I, Beri P, Flapan L, Williams B.
europepmc   +1 more source