Results 121 to 130 of about 326,383 (284)

network: A Package for Managing Relational Data in R [PDF]

open access: yes
Effective memory structures for relational data within R must be capable of representing a wide range of data while keeping overhead to a minimum. The network package provides an class which may be used for encoding complex relational structures composed
Carter T. Butts
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

HOMOMORPHISM IN ROUGH LATTICE

open access: yesJournal of New Theory, 2015
− In this paper, we introduce the concept of set-valued homomorphism of a lattice which isthe generalization of ordinary lattice homomorphism. We construct generalized rough lower and upperapproximations operators, by means of a set-valued mapping, which
Dipankar Rana, Sankar Kumar Roy
doaj  

Weak Asymptotic Stabilizability of Discrete-Time Systems Given by Set-Valued Operators

open access: yesJournal of Mathematical Analysis and Applications, 1996
Let \(T\) be a convex process in a Banach space \(X\) (i.e. \(T\) is a multioperator whose graph is a closed convex cone). A discrete inclusion \[ x(k+1)\in T(x(k)), \qquad k=0,1,\dots \] is said to be weakly asymptotically stabilizable if for every \(x_0\in X\) there is a solution \(x(k)\) such that \(x(0)=x_0\) and \(x(k)\to0\) as \(k\to\infty\). The
openaire   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Metric Approximation of Set-Valued Functions of Bounded Variation by Integral Operators

open access: yesConstructive Approximation
Abstract We introduce an adaptation of integral approximation operators to set-valued functions (SVFs, multifunctions), mapping a compact interval [a, b] into the space of compact non-empty subsets of $${\mathbb {R}}^d$$ R
Berdysheva, Elena E.   +3 more
openaire   +3 more sources

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