Results 71 to 80 of about 504,784 (313)
Online Set Cover with Set Requests.
, 2014 We consider a generic online allocation problem that generalizes the classical online set cover framework by considering requests comprising a set of elements rather than a single element. This problem has multiple applications in cloud computing, crowd sourcing, facility planning, etc.
Bhawalkar, Kshipra +2 more
openaire +3 more sources
Extensions to emergency vehicle location models [PDF]
, 2003 This paper is concerned with extending models for the Maximal Covering Location Problem in two ways. First, the usual 0-1 coverage definition is replaced by the probability of covering a demand within the target time.
Rand, G K, Alsalloum, O I
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The complexity of combinatorial optimization problems on d‐dimensional boxes [PDF]
, 2007 The Maximum Independent Set problem in d-box graphs, i.e., in intersection graphs of axis-parallel rectangles in R-d, is known to be NP-hard for any fixed d >= 2.
Chlebikova, Janka +5 more
core +1 more source
Set covering problems in radio network planning
, 2023 In dieser Bachelorarbeit wird das Problem der Auswahl von Antennenstandorten für eine maximale räumliche Abdeckung in 5G-Funknetzen untersucht. Das Hauptziel besteht darin, eine effiziente Lösung für dieses kombinatorische Optimierungsproblem zu finden ...
Zhong, Lingyu
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
We study a dynamic vNM stable set in a compact metric space under the assumption of complete and continuous dominance relation. Internal and external stability are defined with respect to farsighted dominance.
Hannu Vartiainen
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source