Results 31 to 40 of about 61,414 (267)

Long‐Term Outcomes of Patients With Relapsed/Refractory Neuroblastoma Treated on ANBL1221: A Report From the Children's Oncology Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Results of COG ANBL1221 changed treatment paradigms for patients with relapsed/refractory neuroblastoma. Chemoimmunotherapy with irinotecan/temozolomide/dinutuximab is now used as both bridge therapy following suboptimal response to induction and as treatment in first relapse.
Elizabeth Sokol, Arlene Naranjo, Lulu Chen, Rajen Mody, Steven G. DuBois, Rochelle Bagatell, Navin Pinto   +6 more
wiley   +1 more source

Geometric spatial structure of traditional Tibetan settlements of Degger County, China: A case study of four villages

Frontiers of Architectural Research, 2018
This study investigates the characteristics of spatial elements and structure in a multi-cultural traditional settlement in Degger County, Sichuan Province, in the Tibetan area of China.
Yingzi Zhang, Suolang Baimu, Jing Tong, Wenshuang Wang   +3 more
doaj   +1 more source

Processes of Integration and Fragmentation of Economic Space: The Structure of Settlement Systems [PDF]

Пространственная экономика, 2017
This work presents a study of processes of integration and fragmentation caused by the polarization of economic space. Under integration in economic space the authors understand the formation of new and transformation of existing settlement systems ...
Alexander Pavlovich Goryunov, Anna Vasilyevna Belousova   +1 more
doaj   +1 more source

Improvement of Sickle Cell Disease Care Mitigates the Healthcare Utilization Induced by Increased Prevalence: Experience of a Tertiary Pediatric Center

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) has undergone major changes in the last decades. Its prevalence has been steadily increasing and numerous advances have been made in the management of the disease. However, the effect in real‐life setting of these major changes is unknown, particularly in a Canadian environment. Procedure We aimed to assess
Maude Cigna, Alexia Muresan, Estelle Lecluze, Karine Leduc, Nathalie Fournier, Maria Tamer, Jean‐François Delisle, Jeremi Charbonneau, Annie Viau, Jessica Darilus, Marie‐Joëlle Doré‐Bergeron, Valérie Arsenault, Evelyne Doyon‐Trottier, Stéphanie Forte, Nancy Robitaille, Yves Pastore, Thomas Pincez   +16 more
wiley   +1 more source

Settlement Pattern Features in Mountainous Countries (on the Example of the Republic of Armenia) [PDF]

Население и экономика
Despite the current variety in settlement patterns, mountainous countries share certain similarities in features, characteristics, trends, and issues related to settlement patterns.
Gohar G. Ghambaryan, Aksel H. Potosyan, Vardan G. Mkhitaryan, Vahan A. Potosyan, Anzhela A. Ayriyants   +4 more
doaj   +3 more sources

Settlement-Size Scaling among Prehistoric Hunter-Gatherer Settlement Systems in the New World. [PDF]

PLoS ONE, 2015
Settlement size predicts extreme variation in the rates and magnitudes of many social and ecological processes in human societies. Yet, the factors that drive human settlement-size variation remain poorly understood.
W Randall Haas, Cynthia J Klink, Greg J Maggard, Mark S Aldenderfer   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Evaluation of train-induced settlement for metro tunnel in saturated clay based on an elastoplastic constitutive model

Underground Space, 2018
In this study, a two-dimensional (2D) soil–water coupling dynamic finite element (FE) analysis is conducted to investigate the effect of repeated train vibrations on the long-term settlement of a metro tunnel in saturated clay.
Qiang Huang, Hongwei Huang, Bin Ye, Dongmei Zhang, Feng Zhang   +4 more
doaj   +1 more source

Large Deformation Settlement Series Solution and Numerical Simulation for Underpass Project Track

Applied Sciences, 2023
The settlement of track in a railroad underpass project was studied by theoretical analysis and numerical simulation, based on the model of winkle beam on elastic foundation. Taking the settlement of roadbed as a nonlinear boundary condition, the control
Li Chen, Fengxiao Yu, Yipu Peng
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source