Results 161 to 170 of about 5,249,440 (315)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Foundation model for screening severe mitral regurgitation and severe aortic stenosis from coronary angiograms. [PDF]

Vis Comput Ind Biomed Art
Zhang Y, Shao Z, Wei Z, Liu C, Sun Z, Liu L, Xin R, Ge Y, Wang C, Ding G, Gao L, Zhang L, Hui H, Tian J, Chen Y.   +14 more
europepmc   +1 more source

Severe Hyperkyphosis

Internal Medicine, 2018
openaire   +3 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Dupilumab for the treatment of severe atopic dermatitis in a pregnant patient: A case report

JAAD Case Reports, 2020
Madeeha Mian, MD, Rachel Dunlap, MD, Eric Simpson, MD   +2 more
doaj   +1 more source

Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis. [PDF]

PLOS Glob Public Health
Palmer M, Derks I, Schaaf HS, Goussard P, Jaganath D, Kik SV, Gibb DM, Turkova A, Walters E, van der Zalm MM, Hesseling AC, Seddon JA.   +11 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Clinical Characteristics, Management, and Perinatal Outcomes of Third-Trimester Preeclampsia at a Tertiary Hospital in Vietnam: A Retrospective Descriptive Study. [PDF]

Int J Womens Health
Nguyen KT, Bui TTT, To NTH, Phan QN, Dang NB, Le CTK, Tran NH.   +6 more
europepmc   +1 more source

Severe keratomalacia

Eye
Li, Fang, Zhang, Weijie, Fu, Yao
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source