Results 71 to 80 of about 5,249,440 (315)

Use of oral Janus kinase inhibitors for the treatment of severe alopecia areata: narrative review and real-world experience

open access: yesImmunological Medicine
Alopecia areata (AA) is a common autoimmune, non-scarring hair loss disease in which anagen hair follicles are predominantly affected. Typically, from a single to multiple and round to oval patchy hair loss is observed in AA with a tendency for ...
Manabu Ohyama   +3 more
doaj   +1 more source

Total knee arthroplasty in severe genu valgus. Five to 14 years followup.

open access: yesRevista de la Asociación Argentina de Ortopedia y Traumatología, 2016
Introduction: valgus malalignment is a complex, multiplanar deformity characterized by bone alterations and soft-tissue abnormalities. Several surgical techniques have been described for valgus knee, and the sequence of tight lateral structures release ...
César Angel Pesciallo   +7 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Air transport in Ghana: some climatic constraints

open access: yesAviation, 2012
Understanding a definite geographic context is essential for effective air transport management. To date, the consequences of changing weather conditions and climate on the transportation sector in Ghana has been grievous to the economy of the country ...
Abdul-Wadood Moomen
doaj   +1 more source

Is it severe asthma or asthma with severe comorbidities? [PDF]

open access: yes, 2017
Luisa Brussino,1 Paolo Solidoro,2 Giovanni Rolla1 1Allergy and Clinical Immunology, University of Torino and Mauriziano Hospital, 2SC Pneumologia U, AOU Città della Salute e della Scienza, Torino, Italy Abstract: Severe asthma is defined as asthma
Brussino L, Rolla G, Solidoro P
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Very severe spinal muscular atrophy (Type 0)

open access: yesAvicenna Journal of Medicine, 2017
This case report describes a rare phenotype of very severe spinal muscular atrophy (SMA) in a newborn who presented with reduced fetal movements in utero and significant respiratory distress at birth.
Suleiman Al Dakhoul
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

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