Results 41 to 50 of about 527,818 (203)

High ANO1 expression is a prognostic factor and correlated with an immunosuppressive tumor microenvironment in pancreatic cancer

Frontiers in Immunology
BackgroundAminooctylamine (ANO1) plays an oncogenic role in various cancers. However. its role in pancreatic cancer (PC) has rarely been studied. This study investigated the prognostic value of ANO1 and its correlation with the tumor microenvironment ...
Guangnian Zhang, Zhihui Shu, Jun Yu, Jianshui Li, Pengsheng Yi, Bin Wu, Dawei Deng, Shu Yan, Yong Li, Dongmei Ren, Yifu Hou, Yifu Hou, Chuan Lan   +12 more
doaj   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

The relationship between blood glucose variability, disease severity and prognosis of the patients with acute pancreatitis [PDF]

Waike lilun yu shijian
Objective To explore the relationship between blood glucose variability, disease severity and prognosis of the patients with acute pancreatitis. Methods Total of 242 patients with acute pancreatitis admitted to the department of emergency from January ...
ZHU Shiyi, LU Tingting, XIE Rongli, TAN Dan, FEI Jian, CHEN Erzhen, CHEN Ying, XIA Yi
doaj   +1 more source

Acute pancreatitis following SARS-CoV-2 infection: A case report

SAGE Open Medical Case Reports, 2023
The novel coronavirus 2019 (COVID-19) which is caused by severe acute respiratory syndrome coronavirus-2 was first reported from Wuhan, China in December 2019. Since then, it has caused global crisis and it still continues to be a Public Health Emergency
Ugyen Choden, Sonam Yangzom, Geeta Pradhan, Pema wangchuk   +3 more
doaj   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Bifidobacterium Breve Yang08 Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice

Advanced Science, EarlyView.
A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi, Shuang He, Chengyi Li, Hung Chan, Zhenfeng Liu, Bin Yang, Qing Li   +6 more
wiley   +1 more source

Hypertriglyceridemia and acute pancreatitis: clinical and basic research—a narrative review

Journal of Pancreatology
Hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis (AP), and the incidence of HTG-induced AP (HTG-AP) is rising worldwide as a result of changes in lifestyle and dietary habits.
Lin Gao, Weiqin Li
doaj   +1 more source

Role of Clinical Profile, Comorbidities and Neutrophil Lymphocyte Ratio on Prognosis of Acute Pancreatitis [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Acute pancreatitis is the sudden onset of reversible inflammation of pancreas in which pancreatic enzymes cause autodigestion of the gland. Acute pancreatitis varies from mild (mortality rate
Sreenivasa Rao Sudulagunta, Monica Kumbhat, Mahesh Babu Sudulagunta, Aravinda Settikere Nataraju, Shiva Kumar Bangalore Raja   +4 more
doaj   +1 more source

Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis.

Gastroenterology, 2015
BACKGROUND & AIMS Neutrophils are involved in the development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is regulated.
M. Merza, H. Hartman, Milladur Rahman, Rundk Hwaiz, E. Zhang, E. Renström, Lingtao Luo, M. Mörgelin, S. Regnér, H. Thorlacius   +9 more
semanticscholar   +1 more source

Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans

Annals of Intensive Care, 2018
Background The early prediction of the severity of acute pancreatitis still represents a challenge for clinicians. Experimental studies have revealed the generation of specific halogenated lipids, in particular oleic acid chlorohydrin, in the early ...
Enrique de-Madaria, Xavier Molero, Laia Bonjoch, Josefina Casas, Karina Cárdenas-Jaén, Andrea Montenegro, Daniel Closa   +6 more
doaj   +1 more source