Results 251 to 260 of about 459,655 (287)

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Risk prediction and early intervention strategies for persistent SARS-CoV-2 infection in patients with non-Hodgkin lymphoma: a retrospective cohort study. [PDF]

BMC Pulm Med
Zou W, Zhang J, Li Y, Cao Y, Li J, Zhang Z, Zhang X, Song C, Yang R, Yan Y, Wang Y, Zhang X, Xu Z, Chen J.   +13 more
europepmc   +1 more source

Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases

Cell Proliferation, EarlyView.
Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei, Mengting Wei, Haonan Huang, Ting Fan, Zhichang Zhang, Xiaoyu Song   +5 more
wiley   +1 more source

Airway Basal Stem Cells Inflammatory Alterations in COVID‐19 and Mitigation by Mesenchymal Stem Cells

Cell Proliferation, EarlyView.
Airway basal stem cells derived from COVID‐19 patients demonstrated pronounced goblet cell hyperplasia, inflammatory responses and tendencies toward fibrosis. Co‐culture with mesenchymal stem cells (MSCs) notably reduced these pathological changes, likely due to MSCs' regulatory effects on the interferon signalling pathway.
Sheng Du, Jing Jin, Chunli Tang, Zhuquan Su, Lulin Wang, Xinyuan Chen, Mengni Zhang, Yiping Zhu, Jiaojiao Wang, Chunrong Ju, Xinyu Song, Shiyue Li   +11 more
wiley   +1 more source

Hepatitis B virus associated with severe acute respiratory syndrome coronavirus 2 infection: a case report. [PDF]

J Med Case Rep
Florea CE, Bălaș-Maftei B, Obreja M, Rotaru A, Irimie-Băluță ER, Manciuc C.   +5 more
europepmc   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Understanding the unconventional reemergence of <i>M. pneumoniae</i> epidemics during the COVID-19 pandemic. [PDF]

Transl Pediatr
Liu B, Xu L, Wang Y, Hao C, Jiang W.
europepmc   +1 more source

Platypnea-Orthodeoxia Syndrome in Relation to Severe SARS-CoV-2 Infection. [PDF]

Cureus
Valido T, Chumbo AC, Figueiredo F, Cruz T.   +3 more
europepmc   +1 more source

XEC severe acute respiratory syndrome coronavirus 2 subvariant in Africa: A rising health alarm. [PDF]

J Public Health Afr
Abdulrahim A, Gulumbe BH, Oluwasola MA, Danlami MB, Adebisi YA.   +4 more
europepmc   +1 more source

Computer-aided drug design for the double-membrane vesicle pore complex inhibitors against SARS-CoV-2. [PDF]

Front Microbiol
Han W, Zhou R, Wang R, Dong Y, Muhammad Z, Wang B, Geng J, Wang H, Hou W.   +8 more
europepmc   +1 more source