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Clinical Reviews in Allergy & Immunology, 2003
Severe asthma is a term that is commonly used to describe patients with refractory, brittle, near fatal, and difficult-to-control asthma. Patients with severe asthma typically experience persistent symptoms despite medical therapy, report decreased quality of life and suffer an accelerated loss of lung function.
Nicholas J, Kenyon, Nizar N, Jarjour
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Severe asthma is a term that is commonly used to describe patients with refractory, brittle, near fatal, and difficult-to-control asthma. Patients with severe asthma typically experience persistent symptoms despite medical therapy, report decreased quality of life and suffer an accelerated loss of lung function.
Nicholas J, Kenyon, Nizar N, Jarjour
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Seminars in Perinatology, 2013
Asthma is common among women of reproductive age and affects between 4% and 8% of pregnant women. Pregnancy outcomes are correlated to the degree of asthma severity and control. Approximately one-third of pregnant women with asthma remain stable, a third will have improvement of their asthma, and a third will have worsening of the disease.
Diana Alex, Racusin +2 more
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Asthma is common among women of reproductive age and affects between 4% and 8% of pregnant women. Pregnancy outcomes are correlated to the degree of asthma severity and control. Approximately one-third of pregnant women with asthma remain stable, a third will have improvement of their asthma, and a third will have worsening of the disease.
Diana Alex, Racusin +2 more
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American Journal of Respiratory and Critical Care Medicine, 1999
The National Asthma Education and Prevention Program (NAEPP) Expert Panel II recommended a stepped care pharmacotherapy approach to asthma treatment based on an objective assessment of asthma severity using daytime symptoms, nocturnal symptoms, and physiologic lung function. The worst grade of the individual variables determines overall asthma severity.
G L, Colice +4 more
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The National Asthma Education and Prevention Program (NAEPP) Expert Panel II recommended a stepped care pharmacotherapy approach to asthma treatment based on an objective assessment of asthma severity using daytime symptoms, nocturnal symptoms, and physiologic lung function. The worst grade of the individual variables determines overall asthma severity.
G L, Colice +4 more
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Severe asthma: future treatments
Clinical & Experimental Allergy, 2012SummaryBackgroundPatients with severe refractory asthma have not achieved asthma control, even with high doses of ICS, usually in combination with LABAs and other maintenance treatments.ObjectiveThe most promising approaches currently under investigation are those which reduce airway eosinophils in patients with severe refractory asthma and a ...
O'Byrne, P. M. +2 more
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Chest, 2003
Severe asthma is poorly understood clinically, physiologically, and pathologically. While milder forms of asthma are generally easily treated, more severe forms often remain refractory to the best current medical care. Although some patients with severe asthma have had severe disease for most of their lives, there appears to be a second group that ...
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Severe asthma is poorly understood clinically, physiologically, and pathologically. While milder forms of asthma are generally easily treated, more severe forms often remain refractory to the best current medical care. Although some patients with severe asthma have had severe disease for most of their lives, there appears to be a second group that ...
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American Journal of Respiratory and Critical Care Medicine, 2003
Acute severe asthma remains a major economic and health burden. The natural history of acute decompensations is one of resolution and only about 0.4% of patients succumb overall. Mortality in medical intensive care units is higher but is less than 3% of hospital admissions.
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Acute severe asthma remains a major economic and health burden. The natural history of acute decompensations is one of resolution and only about 0.4% of patients succumb overall. Mortality in medical intensive care units is higher but is less than 3% of hospital admissions.
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Severe asthma: Lessons from the Severe Asthma Research Program
Journal of Allergy and Clinical Immunology, 2007Severe asthma affects only a small percentage of the asthma population. However, these patients remain poorly understood and difficult to treat. Because the numbers are relatively small (10% or less of the asthma population), a network approach with shared protocols, samples, and data provides a unique opportunity to recruit the numbers of subjects ...
Sally E, Wenzel, William W, Busse
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Paediatric Respiratory Reviews, 2006
Persistent childhood asthma is more common in females with atopy with an early onset and may result in significant impairment of lung function. Pathological changes in severe chronic asthma in childhood are only partially defined and correlation between pathology, response to treatment and persistence is imprecise. Failure to respond to usual therapies
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Persistent childhood asthma is more common in females with atopy with an early onset and may result in significant impairment of lung function. Pathological changes in severe chronic asthma in childhood are only partially defined and correlation between pathology, response to treatment and persistence is imprecise. Failure to respond to usual therapies
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Journal of Paediatrics and Child Health, 2016
AbstactAcute exacerbations of asthma are very common reasons for a presentation to emergency departments. This paper focuses on defining the high‐risk group, consideration of the concept of phenotypes of acute asthma, the assessment of severe and life‐threatening exacerbations and an emphasis on the management of the more severe end of the exacerbation
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AbstactAcute exacerbations of asthma are very common reasons for a presentation to emergency departments. This paper focuses on defining the high‐risk group, consideration of the concept of phenotypes of acute asthma, the assessment of severe and life‐threatening exacerbations and an emphasis on the management of the more severe end of the exacerbation
openaire +2 more sources