Results 21 to 30 of about 2,311,361 (335)

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Science, 2020
Interferons interfere with lung repair Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions ...
J. Hadjadj, N. Yatim, L. Barnabei, A. Corneau, J. Boussier, Nikaïa Smith, H. Péré, B. Charbit, V. Bondet, C. Chenevier-Gobeaux, P. Breillat, Nicolas Carlier, R. Gauzit, C. Morbieu, F. Pène, N. Marin, N. Roche, T. Szwebel, S. Merkling, J. Treluyer, D. Veyer, L. Mouthon, C. Blanc, P. Tharaux, F. Rozenberg, A. Fischer, D. Duffy, F. Rieux-Laucat, S. Kernéis, B. Terrier   +29 more
semanticscholar   +1 more source

Immunogenetic Association Underlying Severe COVID-19 [PDF]

Vaccines, 2020
SARS-CoV2 has caused the current pandemic of new coronavirus disease 2019 (COVID-19) worldwide. Clinical outcomes of COVID-19 illness range broadly from asymptotic and mild to a life-threatening situation. This casts uncertainties for defining host determinants underlying the disease severity.
Kendall McCoy, Autumn Peterson, Yun Tian, Yongming Sang   +3 more
openaire   +3 more sources

Efficacy of canakinumab in mild or severe COVID‐19 pneumonia

Immunity, Inflammation and Disease, 2021
Background Clinicians all around the world are currently experiencing a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Several therapeutic strategies have been used until now but, to date, there is no specific therapy to
Katia Falasca, Myriam Di Penta, Claudio Ucciferri, Antonio Auricchio, Marta Di Nicola, Michele Marchioni, Eleonora Celletti, Emanuela Sabatini, Francesco Cipollone, Jacopo Vecchiet   +9 more
doaj   +1 more source

COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]

, 2020
COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx, Blagosklonny, Blagosklonny, Blagosklonny, Colasurdo, Colson, Diaz-Quijano, Du, Erusalimsky, Gerontol, Gorospe, Hoffmann, Häkkinen, Jang, Li, Lisanti, Lisanti, Lu, Masternak, Munster, Musso, Nowakowski, Porter, Subbarao, Subbarao, Tanga, Tremblay, Wilce, Yaron, Yusof, Zhang   +30 more
core   +2 more sources

Compassionate Use of Remdesivir for Patients with Severe Covid-19

New England Journal of Medicine, 2020
Background Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, has shown in vitro activity against SARS-CoV-2. Methods We provided remdesivir on a compassionate-use basis to patients hospitalized with Covid-19, the illness ...
J. Grein, N. Ohmagari, Daniel Shin, G. Diaz, E. Asperges, A. Castagna, T. Feldt, Gary M. Green, M. L. Green, F. Lescure, E. Nicastri, Rentaro Oda, Kikuo Yo, E. Quiros-Roldan, A. Studemeister, John Redinski, Seema Ahmed, J. Bernett, D. Chelliah, Danny Chen, S. Chihara, Stuart H. Cohen, J. Cunningham, A. d’Arminio Monforte, S. Ismail, Hideaki Kato, G. Lapadula, E. L’her, T. Maeno, Sumit Majumder, M. Massari, M. Mora-Rillo, Y. Mutoh, Duc Nguyen, E. Verweij, A. Zoufaly, A. Osinusi, A. DeZure, Yang Zhao, Lijie Zhong, A. Chokkalingam, E. Elboudwarej, L. Telep, Leighann Timbs, Ilana N. Henne, Scott V. Sellers, H. Cao, Susanna K. Tan, Lucinda Winterbourne, P. Desai, R. Mera, A. Gaggar, R. Myers, D. Brainard, R. Childs, T. Flanigan   +55 more
semanticscholar   +1 more source

Genetic susceptibility to severe COVID-19

Infection, Genetics and Evolution, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19) pandemic. Clinical manifestations of the disease range from an asymptomatic condition to life-threatening events and death, with more severe courses being associated with age, male sex, and comorbidities.
Cappadona, Claudio, Rimoldi, Valeria, Paraboschi, Elvezia Maria, Asselta, Rosanna   +3 more
openaire   +2 more sources

Severe COVID‐19 during pregnancy in Sweden, Norway, and Denmark

Acta Obstetricia et Gynecologica Scandinavica, 2023
Introduction Pregnancy is a risk factor for severe coronavirus disease 2019 (COVID‐19) and adverse pregnancy outcomes. We aimed to explore maternal characteristics, pregnancy outcomes, vaccination status, and virus variants among pregnant women admitted ...
Anne K. Örtqvist, Maria C. Magnus, Anna J. M. Aabakke, Stine Kjaer Urhoj, Anne Vinkel Hansen, Anne‐Marie Nybo Andersen, Lone Krebs, Karin Pettersson, Siri E. Håberg, Olof Stephansson   +9 more
doaj   +1 more source

Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 [PDF]

, 2020
Background and purpose Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported.
Boon, Paul, De Herdt, Veerle, Garrez, Ieme, Hemelsoet, Dimitri, Laureys, Guy, Raedt, Robrecht, Vonck, Kristl   +6 more
core   +2 more sources

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

Translational research : the journal of laboratory and clinical medicine, 2020
Acute respiratory failure and a systemic coagulopathy are critical aspects of the morbidity and mortality characterizing infection with severe acute respiratory distress syndrome-associated coronavirus-2, the etiologic agent of Coronavirus disease 2019 ...
C. Magro, J. J. Mulvey, D. Berlin, G. Nuovo, S. Salvatore, J. Harp, Amelia Baxter-Stoltzfus, J. Laurence   +7 more
semanticscholar   +1 more source

COVID-19 Vaccination reduced pneumonia severity

European Journal of Radiology Open, 2022
To investigate the effect of vaccinations and boosters on the severity of COVID-19 pneumonia on CT scans during the period of Delta and Omicron variants.Retrospectively studied were 303 patients diagnosed with COVID-19 between July 2021 and February 2022, who had obtained at least one CT scan within 6 weeks around the COVID-19 diagnosis (-2 to +4 weeks)
Noriaki Wada, Yi Li, Takuya Hino, Staci Gagne, Vladimir I. Valtchinov, Elizabeth Gay, Mizuki Nishino, Bruno Madore, Charles R.G. Guttmann, Sheila Bond, Kousei Ishigami, Gary M. Hunninghake, Bruce D. Levy, Kenneth M. Kaye, David C. Christiani, Hiroto Hatabu   +15 more
openaire   +3 more sources