Results 181 to 190 of about 4,527,439 (244)

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Bleomycin-Induced Acral Dyshidrosiform Eruption: A Rare Cutaneous Toxicity Mimicking Eczema. [PDF]

Clin Case Rep
Mortezazadeh M, Khajeh Mehrizi A, Jahangard-Rafsanjani Z, Majidi Nejad A, Seyyed Mahmoudi ST, Farahmand S, Sarwari JS, Mofidi A.   +7 more
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Case Report: Leflunomide-Induced Cutaneous Eruption in a Patient With Probable Chemotherapy-Associated Inflammatory Polyarthritis. [PDF]

Int J Rheum Dis
Kurt Oktay KN, Aygun S, Yorulmaz E, Geler Kulcu D.   +3 more
europepmc   +1 more source

Dupilumab‐Induced Psoriasis in a Patient with Bullous Pemphigoid

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Nina Matthes, Julian Kött, Finn Abeck, Inga Hansen‐Abeck, Jana Bertels, Nina Booken, Stefan W. Schneider   +6 more
wiley   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Clinical manifestations of drug reaction with eosinophilia and systemic symptoms in pediatric patients

JAAD Case Reports
Suzanne Blackley, MS, Chantal Lemoine-Soto, MD, Li Zhou, MD, PhD, Adaeze Ezeofor, MD, Ying-Chih Lo, MD, PhD, Kimberly G. Blumenthal, MD, MSc, Daniela Kroshinsky, MD, MPH   +6 more
doaj   +1 more source

Hydroxychloroquine-Induced AGEP with Positive Rechallenge: A Case Report and Mini Review of the Literature. [PDF]

Dermatopathology (Basel)
Jovanović K, Umeljic Sočević T, Stepovic M, Milosavljević J, Tomović J, Sovrlić MM, Folić M, Milosavljević MN, Jovanović D, Folić N.   +9 more
europepmc   +1 more source

Response to a combination therapy of cemiplimab and cetuximab in cutaneous squamous cell carcinoma – a case report

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Katja Schabet, Louisa Schielein, Alexander Enk, Jessica C. Hassel   +3 more
wiley   +1 more source