Results 191 to 200 of about 4,253,715 (400)

Single cell sequencing unraveling genetic basis of severe COVID19 in obesity

, 2020
Antoine AbdelMassih, Raghda Fouda, Aya Kamel, Fady Mishriky, Habiba-Allah Ismail, Layla El Qadi, Lauris Malak, Maram M. Mohamed, Mariem Arsanyous, Maysa Hazem, Miral El-Husseiny, Mirette Ashraf, Nada Hafez, Nada AlShehry, Nadine El-Husseiny, Nora AbdelRaouf, Noura Shebl, Nouran Hafez, Nourhan Youssef, Peter Afdal, Rafeef Hozaien, Rahma Menshawey, Rana Saeed, Reem Yasser, Shereen Hesham, Wesam Zakarriah, Shahenda Khattab, Yasmine Elammary, Jianping Ye   +28 more
openalex   +2 more sources

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Metabolic and nutritional status changes after 10% weight loss in severely obese patients treated with laparoscopic surgery vs integrated medical treatment [PDF]

, 2007
Alfonsi L, CONTALDO, FRANCO, del Genio A, del Genio F, del Genio G, FINELLI, CARMINE, MARRA, MAURIZIO, PASANISI, FABRIZIO, Rossetti G   +8 more
core   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Nutritional Consequences of Food Insecurity in a Rural New York State County [PDF]

This study of women with children in a rural county of upstate New York examined the relationships of food insecurity and income with two nutritional consequences (adiposity and fruit and vegetables consumption), and assessed whether disordered eating ...
A. Kendall, B. S Rauschenbach, C. M. Olson, E. A. Frongillo Jr.   +3 more
core  

Comparison of end-tidal and transcutaneous measures of carbon dioxide during general anaesthesia in severely obese adults [PDF]

, 2003
J.L. Griffin, Boyd E. Terry, R.K. Burton, Terry L. Ray, Barbara Page Keller, Alice L. Landrum, Joel O. Johnson, Joseph D. Tobias   +7 more
openalex   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

“Obesity–Years” Burden May Predict Reversibility in Heart Failure With Preserved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2022
Anand Chockalingam, Anand Chockalingam
doaj   +1 more source

Morbid Obesity Associated with Non-Alcoholic Fatty Liver Disease and Complicated by Severe Non-Cirrhotic Portal Hypertension: A Case Report from Rural Kenya

, 2023
Vonwicks C. Onyango, Kenneth H. Makokha, Samuel M Gachie, Boniface Mutiso, Nicholas Muriithi Mutuma, Paul M Kamau   +5 more
openalex   +2 more sources