Advanced Science, EarlyView.Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen +6 more
wiley +1 more source
Gender-Specific Determinants of Severe Obesity Among US Adults: Evidence from the NHANES Data [PDF]
Nirajan Budhathoki, Joseph Inungu
openalex +1 more source
A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals
Advanced Science, EarlyView.This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao +16 more
wiley +1 more source
Risk Factors of Difficult Intubation in Patients with Severe Obesity Undergoing Bariatric Surgery: A Retrospective Cohort Study [PDF]
Ayten Saraçoğlu +12 more
openalex +1 more source
Advanced Science, EarlyView.IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu +9 more
wiley +1 more source
Obesity management in Prader–Willi syndrome: current perspectives
Diabetes, Metabolic Syndrome and Obesity, 2018 Antonino Crinò,1 Danilo Fintini,2 Sarah Bocchini,1 Graziano Grugni3 1Autoimmune Endocrine Diseases Unit, 2Endocrinology Unit, Bambino Gesù Children’s Hospital, Research Institute, Palidoro, Rome; 3Division of Auxology, Italian ...
Crinò A +3 more
doaj
Advanced Science, EarlyView.In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu +10 more
wiley +1 more source
Do obese children experience more severe fractures than nonobese children? A cross-sectional study from a paediatric emergency department [PDF]
, 2014 Charisse Kwan +5 more
openalex +1 more source
The obesity paradox: association of obesity with improved survival in medically managed severe aortic stenosis [PDF]
, 2020 Jinghao Nicholas Ngiam +7 more
openalex +1 more source
Visceral adipose tissue adiponectin predicts excess weight loss after bariatric surgery in females with severe obesity [PDF]
, 2023 Giulia Cantini +9 more
openalex +1 more source