Results 211 to 220 of about 4,253,715 (400)

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Severe obesity in youth

Childhood obesity is one of the most pressing health challenges. In recent years, the number of youth with obesity, especially those with severe obesity, is only increasing. This dissertation focused on youth with the most severe grade of obesity, as they suffer from tremendous physical and psychological consequences, and are often overlooked in ...
openaire   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Pediatric MASLD in Severe Obesity: Current Clinical Perspectives on Diagnosis and Treatment. [PDF]

J Clin Med
Kostrzeba E, Bik-Multanowski M, Brandt-Heunemann S, Małecka-Tendera E, Mazur A, Ranke MB, Wabitsch M, Wójcik M, Zachurzok A, Petriczko E.   +9 more
europepmc   +1 more source

Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification

Advanced Science, EarlyView.
This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...
Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou   +13 more
wiley   +1 more source

Liver Fibrosis as a Predictor of Cardiovascular Risk in Patients with Severe Obesity. [PDF]

J Clin Med
Saidi AN, Theel WB, de Jong VD, van Mil SR, van der Lely AJ, Grobbee DE, Apers J, Beek EVZ, Castro Cabezas M.   +8 more
europepmc   +1 more source

Recommendations for the use of the non‐obese diabetic/severe combined immunodeficiency mouse model in autoimmune and drug‐induced thrombocytopenia: communication from the SSC of the ISTH

, 2015
T. Bakchoul, Jens C. Fuhrmann, Beng H. Chong, Daniel W. Bougie, Richard H. Aster   +4 more
openalex   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Effect of Topiramate on Weight Status in Young Children With Severe Obesity. [PDF]

J Endocr Soc
Salama M, Hassan D, Pittock S, Lteif A, Kumar S.   +4 more
europepmc   +1 more source

Erratum:A Brown Tumor after Biliopancreatic Diversion for Severe Obesity,[Endocrine Journal Vol.56, No.2, 263-268]

, 2009

openalex   +2 more sources