Results 221 to 230 of about 4,253,715 (400)

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Exploring the prevalence of severe obesity in a large teaching hospital. [PDF]

PLoS One
Jerry EE, Scheurwater MA, Ghielen JJP, van Donkelaar I, van Veghel D, Dekker LRC, Nienhuijs SW.   +6 more
europepmc   +1 more source

Myocardial function, mechanics and work by echocardiography in adolescents with severe obesity

Guillermo Larios, Sergio Uribe, Claudia Trincado, Francisca Arancibia-Galilea, Paulo Valderrama, Juan Pablo Espejo, M. Virginia Amézquita, Salesa Barja   +7 more
openalex   +1 more source

Severe pediatric obesity

Severe pediatric obesity is a complex, chronic endocrine disease caused by genetic, environmental, behavioral, socioeconomic and cultural factors. In a minority of children with severe obesity, the obesity phenotype is caused by a singular underlying medical cause interfering with the function of the brain areas that regulate satiety and energy ...
openaire   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Metabolic impact of dietary glycine supplementation in individuals with severe obesity. [PDF]

Sci Rep
Tan HC, Hsu JW, Tai ES, Chacko S, Wu V, Yen PM, Kovalik JP, Jahoor F.   +7 more
europepmc   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Management of a complex tibial fracture in a patient with Prader-Willi syndrome and severe obesity. [PDF]

J Yeungnam Med Sci
Son WS.
europepmc   +1 more source

Effects of an intensive inpatient rehabilitation program in elderly patients with obesity [PDF]

, 2019
Berteotti, M., BIGOLIN, FRANCESCO, Budui, S., Busetto, L., Castiglioni, F., Franceschini, L., Gilli, F., Giordano, F., Leoni, S., Letizia Petroni, M., Salvetti, S., Sartori, E., SCHENA, FEDERICO, Skafidas, S., Taddei, M.   +14 more
core   +1 more source