Results 251 to 260 of about 4,253,715 (400)

Unexpected Diagnosis of Fahr's Disease in a Patient with Severe Obesity and a Heterozygotic Variant in the <i>TMEM67</i> Gene. [PDF]

Genes (Basel)
Piekarska K, Oczoś P, Grzybowska-Adamowicz J, Zmysłowska-Polakowska E, Pietrusiński M, Zmysłowska A.   +5 more
europepmc   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Dysregulation of the FGF21-Adiponectin Axis in a Large Cohort of Patients with Severe Obesity and Liver Disease. [PDF]

Int J Mol Sci
Castañé H, Jiménez-Franco A, Onoiu AI, Cambra-Cortés V, Hernández-Aguilera A, Parada D, Riu F, Zorzano A, Camps J, Joven J.   +9 more
europepmc   +1 more source

Rapid amelioration of respiratory parameters in severely obese patients after percutaneous dilatational tracheotomy [PDF]

, 2015
Sven Kaese, Marie Christine Zander, Johannes Waltenberger, Pia Lebiedz   +3 more
openalex   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Severe obesity associates with maladaptive glomerular haemodynamics clustered with insulin resistance and endothelial dysfunction. [PDF]

Clin Kidney J
Moriconi D, Rovera C, Raggi F, Armenia S, Bruno RM, Solini A.   +5 more
europepmc   +1 more source

Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy [PDF]

, 2007
C Finelli, C Nardelli, F Contaldo, F Pasanisi, G Labruna, G Oriani, G Salvatori, L Sacchetti, P Buono, R Bracale   +9 more
core  

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Bariatric surgery and semaglutide in a youth with juvenile Huntington disease and severe obesity: a case report. [PDF]

J Med Case Rep
Vidmar AP, Martin MJ, Abel S, Kim AG, Muñoz CE, Weitzner M, Derrington SF, Samakar K.   +7 more
europepmc   +1 more source

A Wearable System Featuring Biomimetic Spatially Distributed Iontronic Sensing Array for Dynamic Monitoring of Deep Tissue Modulus

Advanced Science, EarlyView.
A fully wearable system enables real‐time, dynamic, and accurate monitoring of Young's modulus in multilayer tissues containing deep muscle. It demonstrates high accuracy and robustness across simulations, benchtop validations, and human testing. It quantifies edema severity and tracks muscle stiffness during rest, loaded elbow flexion, rope skipping ...
Zhenning Wang, Chaohua Fang, Ruoyu Sun, Chenghao Feng, Xiaoyuan Wang, Hao Bi, Yidan Wu, Jiangdong Gong, Yuyang Wang, Jiahao Guo, Yu Chang, Huizhi Wang, Tingrui Pan   +12 more
wiley   +1 more source