Abstract Objective Individuals with Down syndrome (DS) face an ultra‐high risk of Alzheimer's disease (AD). Within this continuum, Progressive Myoclonus Epilepsy (PME) has emerged as a marker of advanced neurodegeneration. Building on our 2014 characterization of this syndrome, we aimed to define its long‐term natural history and pathological substrate.
Giuseppe d'Orsi +6 more
wiley +1 more source
Serum levels of PTEN and progranulin as potential diagnostic and prognostic biomarkers for severe pneumonia in the elderly. [PDF]
Ge Y, Lu W, Liu J, Liang H, Xu L.
europepmc +1 more source
Abstract Background Antimicrobials are commonly prescribed for the treatment of equine asthma, despite limited evidence supporting their use. Tracheal wash (TW) bacterial culture results are known to influence antimicrobial prescription decisions. Objectives To determine whether a positive TW bacterial culture in horses with asthma is associated with ...
Laurence Leduc +2 more
wiley +1 more source
Cost-effectiveness of bubble continuous positive airway pressure in treating severe pneumonia and hypoxaemia in under-five children in Ethiopia. [PDF]
Negasa AG +8 more
europepmc +1 more source
Longest survivor of pulmonary atresia with ventricular septal defect without surgical intervention
ESC Heart Failure, Volume 12, Issue 2, Page 1499-1507, April 2025.
Sang Zhou +5 more
wiley +1 more source
Diagnosis of bacteraemia in neonatal foals using 16S rRNA high‐throughput sequencing
Abstract Background Sepsis is an important cause of morbidity and mortality in foals. Early diagnosis can improve outcome but is complicated by non‐specific clinical signs and delayed confirmation of infection via blood culture. Molecular assays represent a rapid and more sensitive alternative.
Flavie Payette +7 more
wiley +1 more source
Reach, implementation fidelity, and safety of bubble continuous positive airway pressure (bCPAP) therapy in children with severe pneumonia in Pakistan. [PDF]
Ijaz N +11 more
europepmc +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai +4 more
wiley +1 more source
Current machine learning models for predicting the length of stay for acute stroke lack clinical utility and reliability. This scoping review highlights areas for improvement to develop more robust, interpretable, generalizable, and clinically actionable models that optimize personalized clinical pathways and support precise decision‐making for stroke ...
Zhenran Xu +4 more
wiley +1 more source
Broad-spectrum targeted next-generation sequencing: is it ready for routine deployment in intensive care units for severe pneumonia? [PDF]
Tseng HY +13 more
europepmc +1 more source

