Results 121 to 130 of about 418,889 (208)

Ventilatory Parameters and Adjunctive Therapies Associated with ICU Mortality in Severe Pneumonia: A Large Retrospective Cohort Study. [PDF]

J Clin Med
Nie W, Guo J, Tang N, Liang Z, Zhou Y.
europepmc   +1 more source

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

Clinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal, Fernanda Bortolotto, Mariana Cristina Manoel, Gabriela Silveira de Araújo, Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini, Joab Cabral Ramos, Isabel Schausltz Pereira Faustino   +8 more
wiley   +1 more source

ROS-responsive nanogels enable inhaled CD24 immunotherapy for selective hyperinflammation suppression in severe pneumonia. [PDF]

Sci Adv
Wang X, Zhao X, Zhang F, Wang S, Meng F, Deng C, Ye M, Zhong Z.   +7 more
europepmc   +1 more source

Biventricular Pressure‐Volume Loop Analysis in an LVAD Patient Optimized With Impella RP Flex

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Right ventricular (RV) failure after left ventricular assist device (LVAD) implantation is a serious complication which may necessitate temporary mechanical support in refractory cases. Here we describe a 63‐year‐old man with end‐stage ischemic cardiomyopathy and severe combined pre‐ and post‐capillary pulmonary hypertension who developed ...
Sara S. Inglis, Serena Rahme, Andrew N. Rosenbaum, Atta Behfar   +3 more
wiley   +1 more source

Clinical significance of LINC01093 in children with severe pneumonia and its regulation of miR‑326/MAPK1 axis. [PDF]

BMC Pediatr
Tong P, Wang N.
europepmc   +1 more source

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes. [PDF]

Nat Commun
Jeffrey M, Bartholdson Scott J, Mazumdar S, White RJ, Higginson E, Maes M, Forrest S, Pereira-Dias J, Parmar S, Heasman-Hunt E, Curran MD, Polgarova P, Herre J, Wauters E, Lambrechts D, Van Mol P, Jacobs C, Wauters J, Davenport EE, Baker S, Dougan G, Navapurkar V, Conway Morris A.   +22 more
europepmc   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Characteristics of <i>Chlamydia pneumoniae</i> infection in 141 children with respiratory tract infection and risk factors for severe pneumonia. [PDF]

Front Pediatr
Li S, Chen L, Liu H.
europepmc   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source