Results 111 to 120 of about 2,034,752 (246)

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Diagnosis and treatment experience of Chlamydia psittaci pneumonia: A multicenter retrospective study in China

BMC Infectious Diseases
Background In recent years, clinical cases of Chlamydia psittaci pneumonia have gradually increased. Chlamydia psittaci pneumonia can quickly progress to severe pneumonia, leading to respiratory failure.
Hui Deng, Yeshuang Shi, Mei Xie, Xuelei Zang, Xuefeng Zang, Xidong Ma, Wenya Han, Jiawei He, Youpeng Rao, Maoqian Ding, Wenjuan Ma, Jing Wu, Lei Pan, Xinying Xue   +13 more
doaj   +1 more source

Research progress of biomarkers in evaluating the severity and prognostic value of severe pneumonia in children

Frontiers in Pediatrics
Pneumonia is a serious and common infectious disease in children. If not treated in time, it may develop into severe pneumonia. Severe pneumonia in children is mainly characterized by hypoxia and acidosis, often accompanied by various complications such ...
Weihua Gong, Kaijie Gao, Zhiming Shan, Liu Yang, Panpan Fang, Ci Li, Junmei Yang, Jiajia Ni   +7 more
doaj   +1 more source

The forecasting of development of lung fibrosis after suffering a severe community-acquired pneumonia.

Medičnì Perspektivi, 2018
The article presents data on the possibility of predicting the formation of fibrous chan­ges in 6 and 12 months after the past pneumonia in patients with severe nosocomial pneumonia during the year of prospective observation.
I. V. Avramenko
doaj   +1 more source

SEVERE COMMUNITY-ACQUIRED PNEUMONIA

Critical Care Clinics, 1998
Community-acquired pneumonia (CAP) is likely to be severe in the very elderly, and clinically significant in those with hepatic/ renal insufficiency, cardiopulmonary disease, or, impaired host defenses. Pathogens in mild, moderately severe, and severe CAP are the same. These pathogens determine prognosis, complications, and duration of therapy. Empiric
openaire   +2 more sources

Re‐Thinking Electronic Circuit Design Through Emerging Reconfigurable Field Effect Transistors

Advanced Science, EarlyView.
Graphical illustration of reconfigurable field effect transistor (RFET) operation modes, including n‐type, p‐type, and ambipolar transport, as well as their areas of application discussed in this review: digital circuit design, analog circuit design, post‐Shannon computing, and sensing. ABSTRACT Reconfigurable field‐effect transistors, short RFETs, are
Jens Trommer, Juan P. Martinez, Yuxuan He, Giulio Galderisi, Katrin Pingen, Eduardo Sergio Oliveros‐Mata, Lisa Tellis, Cigdem Cakirlar, Christoph Beyer, Brojogopal Sapui, Joachim Knoch, Klaus Hofmann, Sandro Carrara, Eugenio Cantatore, Max C. Lemme, Ian O'Connor, Akash Kumar, Andre Heinzig, Thomas Mikolajick, Walter M. Weber   +19 more
wiley   +1 more source

A retrospective, single-center analysis of clinical features and mortality risk factors in pediatric pertussis patients with severe pneumonia and encephalopathy complications in Southwest China

Italian Journal of Pediatrics
Background and objective Pertussis remains a serious threat to infants and young children, especially when complicated by pneumonia or encephalopathy.
Yongqin Li, Qifan Wu, Liping Tan, Cong Liu, Xiaoqing Chi   +4 more
doaj   +1 more source

Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium

Advanced Science, EarlyView.
Pediatric acute respiratory distress syndrome (PARDS) suppresses the FOXF1 transcription factor and disrupts lung development. This study shows that the FOXF1‐activating small‐molecule compound, TanFe[F], can be precisely delivered to lung endothelial cells using the innovative LEDD nanoparticle system.
Afzaal N. Mohammed, Zicheng Deng, Arnab Misra, Marcus Orzabal, Ananya Kondapally, Enhong Li, Jonathan Do, Ying‐Wei Lan, Fatemeh Kohram, Hunter Blackburn, Andreas Damianos, Tanya V. Kalin, Vladimir V. Kalinichenko   +12 more
wiley   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source