Results 101 to 110 of about 1,827,911 (290)

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Biomarkers and bacterial pneumonia risk in patients with treated HIV infection: a case-control study [PDF]

, 2013
Background: Despite advances in HIV treatment, bacterial pneumonia continues to cause considerable morbidity and mortality in patients with HIV infection. Studies of biomarker associations with bacterial pneumonia risk in treated HIV-infected patients do
Kunisaki, KM, Brian Angus, Gordin, Fred M., Sarah L Pett, Angus, Brian, Bjerk, Sonja M., Sonja M. Bjerk, Sean Emery, Kunisaki, Ken M, Neuhaus, Jacqueline, Ken M Kunisaki, Jacqueline Neuhaus, Ristola, M., Baker, Jason V., Gordin, FM, Pett, Sarah L, Jason V Baker, Pett, Sarah L., Neuhaus, J, Sonja M Bjerk, Stephan, C, Baker, Jason V, Fred M Gordin, Christoph Stephan, Gordin, Fred M, Bjerk, Sonja M, INSIGHT SMART Study Group, Kunisaki, Ken M., Fred M. Gordin, Stephan, Christoph, Casseb, Jorge Simão do Rosário, Bjerk, SM, Ken M. Kunisaki, Emery, S, Angus, B, Sarah L. Pett, Jason V. Baker, Emery, Sean, Baker, JV, Pett, SL   +39 more
core   +1 more source

Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children

BMC Pediatrics
The aim of this study was to analyze the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children to provide a basis for clinical recognition and diagnosis.This was a retrospective analysis of 130 cases of severe Mycoplasma pneumoniae pneumonia (SMPP), 81 cases of severe Streptococcus pneumoniae ...
Jie Liu, Beibei Bao, Tipei Zhang, Wanyu Jia, Caili Guo, Chunlan Song   +5 more
openaire   +3 more sources

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

The relationship between lactate dehydrogenase and Apolipoprotein A1 levels in patients with severe pneumonia [PDF]

Journal of Medical Biochemistry
Background: To investigate the relationship between lactate dehydrogenase and apolipoprotein A1 levels and the condition and prognosis of patients with severe pneumonia.
Wang Jiang, Wang Ronghua, Zhou Ying, Ma Yao, Xiong Chunyan   +4 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Diagnosis and treatment experience of Chlamydia psittaci pneumonia: A multicenter retrospective study in China

BMC Infectious Diseases
Background In recent years, clinical cases of Chlamydia psittaci pneumonia have gradually increased. Chlamydia psittaci pneumonia can quickly progress to severe pneumonia, leading to respiratory failure.
Hui Deng, Yeshuang Shi, Mei Xie, Xuelei Zang, Xuefeng Zang, Xidong Ma, Wenya Han, Jiawei He, Youpeng Rao, Maoqian Ding, Wenjuan Ma, Jing Wu, Lei Pan, Xinying Xue   +13 more
doaj   +1 more source

Expert Consensus on Influenza Vaccine and Pneumococcal Vaccination in Elderly People With Chronic Respiratory Diseases (2024)

AGING MEDICINE, EarlyView.
This consensus describes the protective effect and safety of influenza and pneumococcal vaccines, and vaccination recommendations, aiming to promote the vaccination rate, better play the role of vaccines in preventing influenza and pneumococcal diseases, and reduce the occurrence of respiratory infections and related serious complications in elderly ...
Lijing Wang, Qiao Yu, Qiong Chen, Pulin Yu, Expert Committee of Consensus Opinion on Influenza Vaccine and Pneumococcal Vaccine Vaccination for Elderly People with Chronic Respiratory Diseases, Respiratory Group of Chinese Geriatrics Society, Yunhua Bai, Yufeng Du, Luzhao Feng, Lidong Gao, Lingyun Gao, Baimei He, Junguang Jiang, Wenjing Jiang, Yayun Nan, Zhibin Peng, Yun Peng, Zhujun Shao, Jin Tan, Yingxuan Tian, Bingxiang Wang, Yuhong Wang, Wei Wu, Jianqin Wu, Xiuping Wu, Meizhe Xin, Wei Xiong, Guogang Zhang, Qiang Zhang, Xiangyu Zhang, Zhimian Zhang, Xiongwen Zhou   +31 more
wiley   +1 more source