Results 71 to 80 of about 3,403,442 (377)

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

A Practical Understanding of Preeclampsia for a Nurse in a Third World Setting [PDF]

, 2019
Preeclampsia is a disease of pregnancy that affects approximately 3-5% of women with child. It is one of the primary causes of mortality in mothers and babies across the globe. The exact cause, pathogenesis, or disease progression is unknown.
Lovin, Anna
core   +1 more source

Doppler sonography of the uterine and the cubital arteries in normal pregnancies, preeclampsia and intrauterine growth restriction: evidence for a systemic vessel involvement [PDF]

, 2006
Aims: The decrease in uterine resistance during normal pregnancy is known to be related to invading trophoblast cells which derive from placental tissue. Uterine and peripheral resistance is elevated in preeclampsia.
Friese, Klaus, Jundt, Katharina, Kainer, Franz, Oberhoffer, Renate, Schiessl, Barbara   +4 more
core   +1 more source

Maternal Vitamin D Status in the Late Second Trimester and the Risk of Severe Preeclampsia in Southeastern China

Nutrients, 2017
The association between maternal vitamin D deficiency and the risk of severe preeclampsia is still debated. In the present study, we aimed to evaluate vitamin D status in Chinese pregnant women and investigate its correlation with the odds of developing ...
Xin Zhao, Rui Fang, R. Yu, Daozhen Chen, Jun Zhao, Jianping Xiao   +5 more
semanticscholar   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Urinary protein and coagulation‐fibrinolysis indicators in preeclampsia: Expression and significance

The Journal of Clinical Hypertension
This study investigates the expression and significance of urinary protein and coagulation‐fibrinolysis indicators in preeclampsia, categorized into mild preeclampsia (109 cases) and severe preeclampsia (97 cases) based on disease severity. Additionally,
Zhen Chen, Fang Fang, Xiaoqian Yu
doaj   +1 more source

Neutrophil count is a useful marker to predict the severity of preeclampsia

Clinical and Experimental Hypertension, 2022
Background At present, pre-eclampsia is a growing concern and still a diagnostic challenge for obstetricians. Aims This study aimed to evaluate whether the relationship of second trimester of pregnancy neutrophil count differed among pregnancies with ...
Miao Liu, Peng Lin, Miaomiao Qu, Ruixia Zhai, Liangjiao Zhang, Lihua Zhang, Liangxi Zhu, Chan Liu, Hua Shu, Xueqin Feng, Chunlong Su, Tiantian Yu, Fengge Wang, Dongmei Man   +13 more
doaj   +1 more source

A possible new approach in the prediction of late gestational hypertension: The role of the fetal aortic intima-media thickness [PDF]

, 2017
The aim was to determine the predictive role of combined screening for late-onset gestational hypertension by fetal ultrasound measurements, third trimester uterine arteries (UtAs) Doppler imaging, and maternal history.
Camerin, Martina, Cosmi, Erich, Grisan, Enrico, Londero, Ambrogio P., Visentin, Silvia   +4 more
core   +1 more source

Micro- and Nano-vesicles from First Trimester Human Placentae Carry Flt-1 and Levels Are Increased in Severe Preeclampsia

Frontiers in Endocrinology, 2017
Background/objectives Preeclampsia is a life-threatening hypertensive disease affecting 3–5% of pregnancies. While the pathogenesis of preeclampsia remains unclear, it is known that placenta-derived factors trigger the disease by activating maternal ...
M. Tong, Qi Chen, J. James, P. Stone, L. Chamley   +4 more
semanticscholar   +1 more source

Women with epilepsy: Evidence‐based counseling across the lifespan

Epilepsia, EarlyView.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert‐Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz   +7 more
wiley   +1 more source