Results 211 to 220 of about 5,229,135 (336)

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Association of automated quantified emphysema and interstitial lung abnormality with survival in non-small cell lung cancer. [PDF]

Insights Imaging
Weng G, Tao J, Pu Y, Liang C, Chen B, Wang Z, Qi C, Zhang J.   +7 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Correlation of triglyceride glucose-body mass index, bedside index for severity in acute pancreatitis, and C-reactive protein-to-lymphocyte ratio with disease severity in patients with hyperlipidemic acute pancreatitis: A retrospective-cohort study. [PDF]

J Int Med Res
Xie R, Zhang Y.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Prevalence and severity of persistent pulmonary hypertension of the newborns among asphyxiated neonates admitted in Enugu State University Teaching Hospital. [PDF]

BMJ Paediatr Open
Okechukwu A, Odetunde O, Uchenna E, Chinawa JM.   +3 more
europepmc   +1 more source

Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos)

Journal of hepato-biliary-pancreatic sciences, 2018
M. Yokoe, J. Hata, T. Takada, S. Strasberg, H. Asbun, G. Wakabayashi, K. Kozaka, I. Endo, D. Deziel, F. Miura, Kohji Okamoto, T. Hwang, Wayne Shih‐Wei Huang, C. Ker, Miin‐Fu Chen, Ho-Seong Han, Yoo-Seok Yoon, I. Choi, D. Yoon, Y. Noguchi, S. Shikata, Tomohiko Ukai, R. Higuchi, T. Gabata, Yasuhisa Mori, Y. Iwashita, T. Hibi, P. Jagannath, E. Jonas, K. Liau, C. Dervenis, D. Gouma, D. Cherqui, G. Belli, O. Garden, M. Giménez, E. Santibanes, Kenji Suzuki, A. Umezawa, A. Supe, H. Pitt, Harjit Singh, A. Chan, W. Lau, A. Teoh, G. Honda, A. Sugioka, K. Asai, H. Gomi, T. Itoi, S. Kiriyama, Masahiro Yoshida, T. Mayumi, Naoki Matsumura, H. Tokumura, S. Kitano, K. Hirata, K. Inui, Y. Sumiyama, Masakazu Yamamoto   +59 more
semanticscholar   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Executive Dysfunction Across Anxiety Severity Level: Evidence for Cognitive Plateau. [PDF]

Ann Neurosci
Srivastava S, Vanzara T, Srivastava A, Pandey S, Bajpai P, Jacob J, Sony KK.   +6 more
europepmc   +1 more source