Results 211 to 220 of about 957,939 (375)

The predictive value of the Oxford Acute Severity of Illness Score for clinical outcomes in patients with acute kidney injury. [PDF]

Ren Fail, 2022
Wang N, Wang M, Jiang L, Du B, Zhu B, Xi X.   +5 more
europepmc   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source

Intestinal permeability in critical illness and acute liver failure: The relationship with severity of illness, spalanchnic ischemia and survival

, 1998
S.M. Gabe, Manthankumar Patel, G. Grimble, Robert H. Williams, I Bjarnson, D.B.A. Silk   +5 more
openalex   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

Severity of illness and organ dysfunction scoring systems in pediatric critical care: The impacts on clinician's practices and the future. [PDF]

Front Pediatr, 2022
Recher M, Leteurtre S, Canon V, Baudelet JB, Lockhart M, Hubert H.   +5 more
europepmc   +1 more source

184 Is the Severity and Outcome of Respiratory Illness of Preterm Neonates with Generalised, Minimal Subcutaneous Edema Different? [PDF]

, 2005
Sunil Jog, Sanjay Patole, Roman‐Ulrich Müller   +2 more
openalex   +1 more source

Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis

Advanced Science, EarlyView.
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang, Ri Tang, Yang Zhou, Jinquan Zhang, Shuya Mei, Yawen Peng, Xi Huang, Shunpeng Xing, Yuan Gao, Qiaoyi Xu, Zhengyu He   +10 more
wiley   +1 more source

Factors affecting the disease severity of COVID-19 patients in an emergency setting

Family Medicine & Primary Care Review, 2022
Samuel Bungaran Partahi Saud Manalu, Elcha Leonard, Carennia Paramita, Marshell Tendean   +3 more
doaj   +1 more source

Effects of physical activity on the severity of illness and mortality in COVID-19 patients: A systematic review and meta-analysis. [PDF]

Front Physiol, 2022
Sittichai N, Parasin N, Saokaew S, Kanchanasurakit S, Kayod N, Praikaew K, Phisalprapa P, Prasannarong M.   +7 more
europepmc   +1 more source

Association of severity of illness and intensive care unit readmission: A systematic review.

Heart & lung : the journal of critical care, 2016
Evan G. Wong, Ann M. Parker, D. Leung, E. Brigham, A. Arbaje   +4 more
semanticscholar   +1 more source