Disparity between General Symptom Relief and Remission Criteria in the Positive and Negative Syndrome Scale (PANSS): A Post-treatment Bifactor Item Response Theory Model. [PDF]
Objective: Total scale scores derived by summing ratings from the 30-item PANSS are commonly used in clinical trial research to measure overall symptom severity, and percentage reductions in the total scores are sometimes used to document the efficacy of
Anderson, Ariana E+5 more
core
Disease Severity and Activity in Bronchiectasis: A Paradigm Shift in Bronchiectasis Management [PDF]
Bronchiectasis has an increasing prevalence and substantial clinical and economic burden. Therefore, physicians should identify patients with bronchiectasis at high risk of disease progression to ensure optimal management in advance. The heterogeneity of
Yunjoo Im+2 more
doaj +1 more source
FGF14 GAA Intronic Expansion in Unsolved Adult‐Onset Ataxia in the Care4Rare Canada Consortium
ABSTRACT Background and Objectives Spinocerebellar ataxias (SCA) represent a clinically and genetically heterogeneous group of progressive neurodegenerative diseases with prominent cerebellar atrophy. Recently, a novel pathogenic repeat expansion in intron 1 of FGF14 was identified, causing adult‐onset SCA (SCA27B). We aimed to determine the proportion
Alexanne Cuillerier+20 more
wiley +1 more source
Background Respiratory pathology is a major driver of mortality in the intensive care unit (ICU), even in the absence of a primary respiratory diagnosis.
Stefanie E. Mason+12 more
doaj +1 more source
ABSTRACT Objective Music interventions have been shown to have beneficial effects on hemodynamic parameters, pain, and anxiety in various medical settings. However, music interventions in the setting of acute stroke have not been studied. The objective of this trial was to perform a pilot feasibility study of music interventions in the setting of acute
Jeffrey J. Fletcher+7 more
wiley +1 more source
Examining a staging model for anorexia nervosa: empirical exploration of a four stage model of severity. [PDF]
Background: An illness staging model for anorexia nervosa (AN) has received increasing attention, but assessing the merits of this concept is dependent on empirically examining a model in clinical samples.
A Holle Von+46 more
core +2 more sources
Objective: To validate the Pulmonary Embolism Severity Index (PESI), which was developed for risk stratification after acute pulmonary embolism (PE), for use in Brazil. Methods: This was a single-center retrospective study involving patients admitted to
Leonardo de Araujo Soriano+5 more
doaj +1 more source
Regularization of linear ill-posed problems involving multiplication operators [PDF]
We study regularization of ill-posed equations involving multiplication operators when the multiplier function is positive almost everywhere and zero is an accumulation point of the range of this function. Such equations naturally arise from equations based on non-compact self-adjoint operators in Hilbert space, after applying unitary transformations ...
arxiv
Exponential relaxation data analysis by parametrized regularization of severely ill-posed Fredholm integral equations of the first kind [PDF]
This paper presents a novel approach to construct regularizing operators for severely ill-posed Fredholm integral equations of the first kind by introducing parametrized discretization. The optimal values of discretization and regularization parameters are computed simultaneously by solving a minimization problem formulated based on a regularization ...
arxiv
Clinical Phenotyping of Long COVID Patients Evaluated in a Specialized Neuro‐COVID Clinic
ABSTRACT Objective To report Long COVID characteristics and longitudinal courses of patients evaluated between 4/14/21–4/14/22 at the University of Pennsylvania Neurological COVID Clinic (PNCC), including clinical symptoms, neurological examination findings, and neurocognitive screening tests from a standardized PNCC neurological evaluation approach ...
Luana D. Yamashita+7 more
wiley +1 more source