Results 151 to 160 of about 175,590,241 (301)

Incorporating severity of illness into estimates of likelihood ratios

, 2010
Although severity of illness may affect the usefulness of a diagnostic test, most previous work has considered test performance only in the dichotomous situation where the target disorder is considered present or absent. In this paper, a clinical example
Kiefe, Catarina I., Lichtenstein, Michael   +1 more
core  

The Index of Number of Events and Severity (INES): A Novel Instrument for Quantifying Lifetime Illness Burden in Bipolar Disorder

Bipolar disorder (BD) is a chronic psychiatric condition affecting approximately 1-2% of the population, characterized by depressive and manic episodes.
Maria P. Rodriguez-Gomez, Lucia Albarracin-Garcia, Laura Jimenez-Munoz, Enrique Baca-Garcia, Diego Romero-Miguel, Elisabet Madridejos-Palomares, Ines Carpio-Lopez, Ines Garcia-Ortiz, Claudio Toma   +8 more
core   +1 more source

Neuromorphic Optical Tracking and Imaging of Randomly Moving Targets Through Dynamic Dense Scattering Media

Advanced Science, EarlyView.
Vision begins not with images but with change: the retina fires only when something moves, handing the brain a stream of spikes. A neuromorphic imaging system adopts the same strategy—an event sensor that sees like the retina, a spiking network that thinks like the brain—to track and reconstruct fully randomly moving targets through tissue (phantom ...
Ning Zhang, Arto Nurmikko
wiley   +1 more source

Lung Parenchymal and Airway Injuries: Differential Diagnosis and Severity Grading

Journal of the Korean Society of Radiology
Lung parenchymal and airway injuries are common and potentially life-threatening complications of thoracic trauma, requiring rapid and accurate radiological evaluation for optimal patient management.
You Na Kim, Seulgi You, Joo Sung Sun
doaj   +1 more source

Clozapine Augmentation Strategies and Clinical Predictors of Prolonged Tertiary Hospitalization in Clozapine-Resistant Schizophrenia: a Retrospective Cohort Study. [PDF]

Schizophr Bull
Baldwin K, Honer WG, Shahbazi R, Fredrikson D, White RF, Villa-Rodriguez F, Rafizadeh R.   +6 more
europepmc   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Factors Associated with Invasive Mechanical Ventilation Requirement in Older ICU Patients: The Roles of Frailty, Comorbidity, and Acute Illness Severity. [PDF]

Biomedicines
Çakırer M, Düzgün A.
europepmc   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Psychological and Contextual Factors of AI Acceptance Among Informal Caregivers of People Living With Dementia: Cross-Sectional Pilot Study. [PDF]

JMIR Form Res
Fisher L, Hoang MN, DuBose L, Fan Q.
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source