Results 211 to 220 of about 467,474 (338)

Prognostic Value of Inflammatory Biomarkers for Mortality in Intensive Care Patients with Acute Pulmonary Embolism: A Retrospective Observational Study. [PDF]

Clin Appl Thromb Hemost
Zhou M, Xiao L, Chen H, Lin X, Lin S, Lin R.   +5 more
europepmc   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Efficacy of a mechanism-based psychological intervention for persistent gastrointestinal symptoms in ulcerative colitis and irritable bowel syndrome: results of a three-arm randomised controlled trial (SOMA.GUT-RCT). [PDF]

EClinicalMedicine
Maehder K, Peters L, Hübener S, Matysiak A, Huber S, Toussaint A, Zapf A, Vettorazzi E, Weber P, Stahlmann K, Andresen V, Nestoriuc Y, Lohse AW, Löwe B.   +13 more
europepmc   +1 more source

The Severity of Acute Illness and Functional Trajectories in Hospitalized Older Medical Patients

The journals of gerontology. Series A, Biological sciences and medical sciences, 2017
F. Fimognari, A. Pierantozzi, W. De Alfieri, B. Salani, S. Zuccaro, Andrea Arone, Giacomo Palleschi, L. Palleschi   +7 more
semanticscholar   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Latent Classes in Long-Term Functional Status in Children With Recurrent Critical Illness. [PDF]

Crit Care Med
Heneghan JA, Velusamy KR, Ramgopal S, Goodman DM, Evans MD, Hallman M, Feldman A, Akande MY.   +7 more
europepmc   +1 more source

Sulfate‐Directed Silver Dendrites with Enhanced Stability for Ultrasensitive SERS‐Based Therapeutic Drug Monitoring

Advanced Science, EarlyView.
This study presents sulfate‐directed silver dendrites (s‐AgDs) as oxidation‐resistant SERS substrates with long‐term stability, reproducibility, and sub‐picomolar sensitivity. Sulfate ions guide anisotropic growth and protect the surface, enabling improved performance over 7 months under ambient conditions.
Aradhana Dwivedi, Jan Dellith, Anna Makarova, Samir F. El‐Mashtoly, Juergen Popp, Vladimir Sivakov, Dana Cialla‐May   +6 more
wiley   +1 more source

Phase-Related Resting Energy Expenditure in Critically Ill Adults: Metabolic Phenotypes and Determinants of Weight-Normalized Indices-A Retrospective Study. [PDF]

J Clin Med
Chapela S, Cagua-Ordoñez J, Angamarca-Iguago J, Tettamanti D, Kecskes C, Asparch J, Gutierrez FJ, Llobera N, Rella M, Montalván M, Reberendo MJ, Pozo MO, Álvarez-Córdova L, Simancas-Racines D.   +13 more
europepmc   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source