Results 101 to 110 of about 662,113 (303)

Warning indicators of COVID-19 severity: a retrospective observational study integrating modern biomarkers and traditional tongue features

Frontiers in Medicine
ObjectiveThis study aims to identify early warning indicators of COVID-19 severity by integrating modern medical biomarkers with traditional Chinese medicine (TCM) tongue features.MethodsA retrospective observational study was conducted on 409 ...
Zhang Jing, Zhang Jing, Liu Yuntao, Zheng Danwen, Ye Gangfu, Chen Qiumin, Huang Jianshan, Wang Jiamei, Ma Zengming, Zhang Zhongde   +9 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Combination of exhaled volatile organic compounds with serum biomarkers predicts respiratory infection severity

Pulmonology
Objective During respiratory infections, host-pathogen interaction alters metabolism, leading to changes in the composition of expired volatile organic compounds (VOCs) and soluble immunomodulators.
Patricia Esteban, Santiago Letona-Gimenez, Maria Pilar Domingo, Elena Morte, Galadriel Pellejero-Sagastizabal, Maria Del Mar Encabo, Ariel Ramírez-Labrada, Rebeca Sanz-Pamplona, Julián Pardo, José Ramón Paño, Eva M. Galvez   +10 more
doaj   +1 more source

Serum Adiponectin Predicts COVID-19 Severity

Biomedicines
Adiponectin is primarily known for its protective role in metabolic diseases, and it also possesses immunoregulatory properties. Elevated levels of adiponectin have been observed in various inflammatory diseases. However, studies investigating adiponectin levels in the serum of COVID-19 patients have yielded conflicting results.
Pavel, Vlad, Räth, Ulrich, Schmid, Stephan, Krautbauer, Sabrina, Keller, Dennis, Amend, Pablo, Müller, Martina, Mester, Patricia, Buechler, Christa   +8 more
openaire   +4 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Evaluation of Serum Kallistatin Levels in Women with Preeclampsia and its Role in Assessing Preeclampsia Severity

Mustansiriya Medical Journal
Background: Preeclampsia (PE) is a hypertension condition that often manifests after 20 weeks of gestation. It is regarded as a leading cause of death among mothers and babies globally. Aim: To evaluate how serum kallistatin affects PE severity. Patients
Rangeen Badri Mahdi, Esraa Hameed Al-Maini   +1 more
doaj   +1 more source

Dissecting racial bias in an algorithm used to manage the health of populations. [PDF]

, 2019
Health systems rely on commercial prediction algorithms to identify and help patients with complex health needs. We show that a widely used algorithm, typical of this industry-wide approach and affecting millions of patients, exhibits significant racial ...
Mullainathan, Sendhil, Obermeyer, Ziad, Powers, Brian, Vogeli, Christine   +3 more
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Analyzing Crash Severity: Human Injury Severity Prediction Method Based on Transformer Model

Vehicles
Traffic accident-related injuries and fatalities are a serious global public health and social development challenge. The accurate prediction of crash severity improves road safety and reduces casualties, as well as serving road managers and policy ...
Yalan Jiang, Xianguo Qu, Weiwei Zhang, Wenfeng Guo, Jiejie Xu, Wangpengfei Yu, Yang Chen   +6 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source