Results 161 to 170 of about 31,435,271 (262)

Haplotype-resolved genome assembly of a male Dioscorea alata cultivar reveals the structure and evolution of young sex chromosomes. [PDF]

Plant J
Dossa K, Su X, Zoclanclounon YAB, Chen Y, Nawaz MA, Ni P, Qiu T, Chen G, Malédon E, Gravillon MC, Perrot C, Nudol E, Laurent L, Diouf M, Dobrev PI, Karikari B, Fouks B, Arnau G, Mournet P, Wang J, Chaïr H.   +20 more
europepmc   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

The Role of <i>Amh</i> in Gonadal Development and Its Response to Exogenous Hormones in Blotched Snakehead (<i>Channa maculata</i>). [PDF]

Int J Mol Sci
Qin J, Deng Y, Lu Y, Zhang Y, Liu L, Luo Q, Liu H, Fei S, Sun Y, Zhao J, Ou M.   +10 more
europepmc   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

An X-linked sex determination mechanism in cannabis and hop. [PDF]

Nat Commun
Carey SB, Bentz PC, Lovell JT, Akozbek LM, Myers ZA, Korani W, Havill JS, Padgitt-Cobb L, Lynch RC, Allsing N, Mangels J, Stansell Z, Stack GM, Gordon T, Osmanski A, Easterling KA, Orozco LR, Marcus ZE, Hale H, McCoy H, Meharg Z, Grimwood J, Smart LB, Vergara D, Guerrero RF, Kane NC, Fletcher R, McKay JK, Michael TP, Muehlbauer GJ, Clevenger J, Harkess A.   +31 more
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Immunohistochemical characterization of neural stem cells in brains of adult brachycephalic dogs in comparison with canine oligodendroglioma cells. [PDF]

J Vet Med Sci
Tokuno H, Yoshida K, Chambers JK, Uchida K.   +3 more
europepmc   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Telomere-to-telomere genome assembly and a pangenome for the rat. [PDF]

Cell Genom
Li K, Ciosek JL, Koren S, Phillippy AM, Zhu Y, Lauer WA, Brooks SY, Bouffard GG, Pickett BD, Dumont BL, Smith ML, Kalbfleisch TS, Doris PA.   +12 more
europepmc   +1 more source