Results 91 to 100 of about 6,169,236 (312)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

GnRH analogs as a monotherapy in transgender and gender-diverse adolescents: clinical insights from a single-center study

Endocrine Connections
Background: Gonadotropin-releasing hormone agonists (GnRHas) are widely used in the treatment of transgender and gender-diverse adolescents to prevent the development of undesired physical changes.
Fleur A H Lahaije, Petra A van Setten, Willemien Levels, Karlijn Becking-Malpasso, Hedi L Claahsen-van der Grinten   +4 more
doaj   +1 more source

An Assessment of Social Worker Attitudes Regarding the Domestic Sex Trafficking of Children in America [PDF]

, 2010
Human sex trafficking, defined as a “modern-day form of slavery in which a commercial sex act is induced by force, fraud, or coercion, or in which the person induced to perform such an act is under the age of 18 years” (USDHHS, 2009) is a problem that ...
Bergeron, Becky
core   +1 more source

Sex [PDF]

Current Biology, 2014
Lehtonen, Jussi, Kokko, Hanna
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

'It is like a tomato stall where someone can pick what he likes': structure and practices of female sex work in Kampala, Uganda. [PDF]

, 2013
BACKGROUND: Effective interventions among female sex workers require a thorough knowledge of the context of local sex industries. We explore the organisation of female sex work in a low socio-economic setting in Kampala, Uganda.
A-M Cote, AH Norris, C Harcourt, D Whittaker, F Scorgie, F Van den Borne, G Asiki, I Vanwesenbeeck, IB Zablotska, J Bukenya, J Nazziwa, J Seeley, J Vandepitte, J Vandepitte, JAA Munoz, Janet Seeley, JP Ntozi, Judith Vandepitte, K Fritz, L Van Blerk, M Gysels, M Mbonye, Martin Mbonye, ML Rekart, NTT Thuy, PM Pyett, QA Karim, Rachel King, S Baral, S Jana, Sarah Nakamanya, SC Kalichman, SE Woolf-King, UNAIDS, Winifred Nalukenge   +34 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Gender‐specific health implications of minority stress among lesbians and gay men

Australian and New Zealand Journal of Public Health, 2016
Objectives: Lesbians and gay men are exposed to unique minority stressors. We examined the health implications of one type of distal minority stressor (victimisation) and one type of proximal minority stressor (sexual identity concealment due to ...
Emily Bariola, Anthony Lyons, William Leonard   +2 more
doaj   +1 more source

Implementation of hepatitis C cure in Australia: one year on

Journal of Virus Eradication, 2018
Objectives: Direct-acting antivirals (DAAs) for the treatment of hepatitis C (HCV) became universally available in Australia in March 2016, with an aim to achieve HCV elimination. Fourteen per cent of Australians with HCV have initiated treatment.
Jacqueline A. Richmond, Jack Wallace
doaj   +1 more source