Results 121 to 130 of about 4,124,044 (305)

Supervised machine learning identifies impaired mitochondrial quality control in β-cells with development of type 2 diabetes

npj Systems Biology and Applications
Defining molecular pathways driving β-cell failure in type 2 diabetes (T2D) is challenging given donor heterogeneity. We developed an interpretable machine learning framework coupling sparse rule-based classification, pathway constrained modeling, and ...
Mirza Muhammad Fahd Qadir, Charles Dana, Madeleine Pittigher, Paul Mauvais-Jarvis, Nazmul Haque, Theodore Dos Santos, Patrick E. MacDonald, Kyle J. Gaulton, Franck Mauvais-Jarvis   +8 more
doaj   +1 more source

Drug law reform

, 2016
The Australian Sex Party would see personal drug use decriminalised. Most people who use illicit drugs are not physically or psychologically harmed by their use. The current ‘war on drugs’ (i.e., prohibition) does not reduce drug use or drug-related harm
Australian Sex Party
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

LGBTIQ asylum seekers

, 2016
On an international level, Australia performs well regards to its treatment of its LGBTIQ citizens. This standard of treatment does not, however, extend to LGBTIQ asylum seekers in Australia’s care.
Australian Sex Party
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Sex-related oxylipins.

, 2016
Sex-related oxylipins.
Masahiro Tohkin (3545243), Kazuo Okemoto (440938), Yoshiro Saito (195372), Keiko Maekawa (535674), Yoko Tajima (535678)   +4 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Social preferences and psychopathy in a sample of male prisoners—a pilot study

Scientific Reports
Social decisions are influenced by a person’s social preferences. High psychopathy is defined by antisocial behaviour, but the relationship between psychopathy and social preferences remains unclear.
Benjamin J. Kuper-Smith, Alexander Voulgaris, Peer Briken, Johannes Fuss, Christoph W. Korn   +4 more
doaj   +1 more source

''Sex Changes'? Paradigm Shifts in 'Sex' and 'Gender' Following the Gender Recognition Act?' [PDF]

Gender transformations are normatively understood as somatic, based on surgical reassignment, where the sexed body is aligned with the gender identity of the individual through genital surgery – hence the common lexicon \'sex change surgery\'. We suggest
Stephen Whittle, Lewis Turner
core