Results 91 to 100 of about 1,776,164 (231)
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source
Multi-sided Bohm-Bawerk assignment markets: the core [PDF]
We introduce the class of multi-sided B ohm-Bawerk assignment games, which generalizes the well-kown two-sided B ohm-Bawerk assignment games to situations with an arbitrary number of sectors. We reach the extreme core allocations of any multi-sided B ohm-
Oriol Tejada
core
Advanced Science, EarlyView.ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao +7 more
wiley +1 more source
, 2007 "January 8, 2007."; "Established by the Kansas Criminal Justice Coordinating Council."; The Kansas Sex Offender Policy Board would like to recognize the work of staff that assisted the Board in its work, Joshua Mosier and Haley DaVee who prepared the ...
Kansas Sex Offender Policy Board.
core
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Advanced Science, EarlyView.A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun +15 more
wiley +1 more source
Male sex assignment in severely virilized 46,XX children with congenital adrenal hyperplasia. [PDF]
Front Endocrinol (Lausanne)Beniczky NJ +8 more
europepmc +1 more source
Advanced Science, EarlyView.A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li +15 more
wiley +1 more source
Assignment submarkets with a segment core [PDF]
The Böhm-Bawerk horse markets are assignment markets with homogeneous goods that are known to have a one-dimensional core. We show here that, although there exist two-sided assignment games with non-homogeneous products and with a segment as a core, the
Marina Nunez, Carles Rafels
core
Advanced Science, EarlyView.Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng +10 more
wiley +1 more source