Results 131 to 140 of about 60,046 (266)
rDNA Copy Number Variation and Methylation During Normal and Premature Aging
Aging Cell, EarlyView.In > 160 healthy individuals the absolute rDNA copy number (CN) in blood ranged from approximately 240 to 900. The number of active copies with a completely unmethylated promoter varied from 40 to 120, independent of absolute CN. Promoter methylation is a compensation mechanism for absolute CN variation. Aging was associated with a loss of unmethylated
Alva B. C. Geisen +5 more
wiley +1 more source
Aging Cell, EarlyView.Healthy aging is accompanied by transcriptional dysregulation in retinal cells, leading to alterations in key molecular pathways and cellular responses, with the scotopic pathway being particularly affected. We show that rod photoreceptors, essential for initiating scotopic (low‐light) vision, exhibit selective vulnerability to aging‐associated ...
Laura Campello +5 more
wiley +1 more source
Aging Cell, EarlyView.In Qprt‐deficient mice, testicular NAD+ levels decline accelerated with age, leading to mitochondrial dysfunction, disrupted DSB repair, impaired meiotic sex chromosome inactivation, and germ cell loss. Nicotinamide riboside (NR) supplementation restores NAD+ levels and alleviates these defects, highlighting the importance of NAD+ de novo synthesis in ...
Yining Xu +9 more
wiley +1 more source
Aging Cell, EarlyView.The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai +7 more
wiley +1 more source
Triple sex chromatin, and other sex chromatin anomalies, in tumours of females. [PDF]
British Journal of Cancer, 1967 openaire +3 more sources
Allergy, EarlyView.Abbreviations: BLOC1S1, biogenesis of lysosome organelles complex 1 subunit 1; cGAS, cyclic GMP‐AMP synthase; GATA3, GATA binding protein 3; IgE, immunoglobulin E; IKK, inhibitor of nuclear factor kappa‐B kinase; IL, interleukin; mtDNA, mitochondrial DNA; NF‐κB, nuclear factor‐kappa B; OVA, ovalbumin; MC903, vitamin D3 analog; STING, stimulator of ...
Rahul Sharma +8 more
wiley +1 more source
SSTY proteins co-localize with the post-meiotic sex chromatin and interact with regulators of its expression. [PDF]
FEBS J, 2014 Comptour A +8 more
europepmc +1 more source
Genomic technologies and the diagnosis of 46, XY differences of sex development
Andrology, EarlyView.Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris +2 more
wiley +1 more source
Chromatin Structure Around Long Non-Coding RNA (lncRNA) Genes in <i>Schistosoma mansoni</i> Gonads. [PDF]
Noncoding RNAAugusto RC +3 more
europepmc +1 more source