Results 141 to 150 of about 123,835 (338)

Clinical and genetic features of multiple primary tumours cohorts with a renal cell carcinoma: Implications for molecular genetic investigations

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Current knowledge of the genetic architecture underlying the development of renal cell carcinoma‐related multiple primary tumours is limited. The authors comprehensively analysed the results of exome/genome sequencing cohorts including 534 patients to better define genotype–phenotype correlations.
Huairen Zhang   +6 more
wiley   +1 more source

The Impediment of Impotency and the Condition of Male Impotence: A Canonical-Medical Study: Part II, Medical Considerations [PDF]

open access: yes, 1959
To present the problems involved in the matter of male impotence as related to the validity of marriage, the canonical considerations, as prepared by Rev. Paul v.
Harrington, Paul V.   +1 more
core   +2 more sources

New cell lines expanding the diversity of Ewing sarcoma models

open access: yesInternational Journal of Cancer, EarlyView.
What's New? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff   +13 more
wiley   +1 more source

FIGO committee opinion: Environmental drivers of gynecologic and reproductive health

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract This FIGO committee opinion paper addresses the growing body of evidence linking environmental exposures to common gynecologic and reproductive conditions across the life course. From adolescence through menopause, women are exposed to a wide range of environmental toxicants, including endocrine‐disrupting chemicals, air pollutants, heavy ...
Nathaniel DeNicola   +9 more
wiley   +1 more source

The single-cell chromatin landscape in gonadal cell lineage specification

open access: yesBMC Genomics
Gonad development includes sex determination and divergent maturation of the testes and ovaries. Recent advances in measuring gene expression in single cells are providing new insights into this complex process.
Hoi Ching Suen   +5 more
doaj   +1 more source

Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes

open access: yesiMetaOmics, EarlyView.
Prmt5AKO downregulates genes related to fatty acid transport and triacylglycerol synthesis, while upregulating genes involved in glucose transport and cholesterol biogenesis. These changes cause alternation in lipid composition and metabolic phenotypes of Prmt5AKO mice. Abstract The adipose tissue (AT) is a main regulator of systemic energy homeostasis,
Xiyue Chen   +7 more
wiley   +1 more source

Phenothiazine Derivatives and Their Impact on the Apoptosis Processes: A Review

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Phenothiazine derivatives have been used for decades as antipsychotic drugs in multiple mental health and physical conditions treatment (schizophrenia, mania in bipolar disorder, and psychosis). Epidemiological studies have shown that people with schizophrenia are less likely to suffer from cancer, which indicates the ability of antipsychotics
Michał Otręba   +4 more
wiley   +1 more source

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