Results 171 to 180 of about 60,046 (266)

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Functional Study of Four Histone Genes Involved in the Spermatogenesis of Cynoglossus semilaevis. [PDF]

Animals (Basel)
Sun X, Li Z, Wang L, Yan H, Li X, Wang N, Dong Z, Xu W.   +7 more
europepmc   +1 more source

Ezh2 Regulates Early Astrocyte Morphogenesis and Influences the Coverage of Astrocytic Endfeet on the Vasculature

Cell Proliferation, EarlyView.
Ezh2‐deficient astrocytes showed morphologically more slender but sparse dendrites, resulting in reduced endfoot coverage and also causing disruption of the blood–brain barrier. ABSTRACT Astrocytes are crucial for central nervous system (CNS) development and function, with their differentiation being stringently controlled by epigenetic mechanisms ...
Xinghua Zhao, Mengtian Zhang, WenZheng Zou, Chenxiao Li, Shukui Zhang, Yuqing Lv, Libo Su, Fen Ji, Jianwei Jiao, Yufei Gao   +9 more
wiley   +1 more source

BMAL1 is a Critical Regulator of Sex-Specific Gene Expression in the Heart. [PDF]

Function (Oxf)
Dierickx P.
europepmc   +1 more source

Adaptive functioning in children and young adults with monogenic neurodevelopmental disorders

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16264 Abstract Aim To examine the adaptive behaviour profiles of children with monogenic neurodevelopmental disorders (NDDs) to determine whether syndrome‐specific or transdiagnostic approaches provide a better understanding of the adaptive behavioural phenotypes of these NDDs ...
Emma K. Baker, Miya St John, Ruth Braden, Lottie D. Morison, Elana J. Forbes, Fatma Lelik, Stephen J. C. Hearps, David J. Amor, Angela T. Morgan   +8 more
wiley   +1 more source

Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians. [PDF]

Biology (Basel)
Ogielska M, Chmielewska M, Rozenblut-Kościsty B.   +2 more
europepmc   +1 more source

Clinical whole genome sequencing in pediatric epilepsy: Genetic and phenotypic spectrum of 733 individuals

Epilepsia, EarlyView.
Abstract Objective A large proportion of pediatric epilepsies have an underlying genetic etiology. Limited studies have explored the efficacy of whole genome sequencing (WGS) in a clinical setting. Our academic–clinical center implemented clinical whole exome sequencing (WES) in 2014, then transitioned to WGS from 2015.
Olivia J. Henry, Sofia Ygberg, Michela Barbaro, Nicole Lesko, Leif Karlsson, Lucía Peña‐Pérez, Ann Båvner, Virpi Töhönen, Anna Lindstrand, Tommy Stödberg, Anna Wedell   +10 more
wiley   +1 more source

Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes. [PDF]

EMBO J
Qadir MMF, Elgamal RM, Song K, Kudtarkar P, Sakamuri SSVP, Katakam PV, El-Dahr SS, Kolls JK, Gaulton KJ, Mauvais-Jarvis F.   +9 more
europepmc   +1 more source

Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single‐nucleus multiomics

Epilepsia, EarlyView.
Abstract Objective Mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) are brain lesions associated with focal epilepsy and characterized by increased oligodendroglial density, heterotopic neurons, and hypomyelination in the white matter.
Isabella C. Galvão, Manuela Lemoine, Ludmyla Kandratavicius, Clarissa L. Yasuda, Marina K. M. Alvim, Enrico Ghizoni, Ingmar Blümcke, Fernando Cendes, Fabio Rogerio, Iscia Lopes‐Cendes, Diogo F. T. Veiga   +10 more
wiley   +1 more source

piRNA processing within non‐membrane structures is governed by constituent proteins and their functional motifs

The FEBS Journal, EarlyView.
The silencing of transposable elements is mediated by piRNAs through post‐transcriptional and transcriptional regulation. In Drosophila, piRNAs are processed within unique non‐membrane structures: nuage in germline cells and Yb bodies in somatic gonadal cells.
Ritsuko Suyama, Toshie Kai
wiley   +1 more source