Results 11 to 20 of about 60,046 (266)

Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells [PDF]

eLife
Accurate specification of female and male germ cells during embryonic development is critical for sexual reproduction. Primordial germ cells (PGCs) are the bipotential precursors of mature gametes that commit to an oogenic or spermatogenic fate in ...
Adriana K Alexander, Karina F Rodriguez, Yu-Ying Chen, Ciro Amato, Martin A Estermann, Barbara Nicol, Xin Xu, Humphrey HC Yao   +7 more
doaj   +2 more sources

3D chromatin maps of a brown alga reveal U/V sex chromosome spatial organization [PDF]

Nature Communications
Nuclear three dimensional (3D) folding of chromatin structure has been linked to gene expression regulation and correct developmental programs, but little is known about the 3D architecture of sex chromosomes within the nucleus, and how that impacts ...
Pengfei Liu, Jeromine Vigneau, Rory J. Craig, Josué Barrera-Redondo, Elena Avdievich, Claudia Martinho, Michael Borg, Fabian B. Haas, Chang Liu, Susana M. Coelho   +9 more
doaj   +2 more sources

INO80 regulates chromatin accessibility to facilitate suppression of sex-linked gene expression during mouse spermatogenesis. [PDF]

PLoS Genetics
The INO80 protein is the main catalytic subunit of the INO80-chromatin remodeling complex, which is critical for DNA repair and transcription regulation in murine spermatocytes.
Prabuddha Chakraborty, Terry Magnuson
doaj   +2 more sources

ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse [PDF]

eLife
We present evidence implicating the BAF (BRG1/BRM Associated Factor) chromatin remodeler in meiotic sex chromosome inactivation (MSCI). By immunofluorescence (IF), the putative BAF DNA binding subunit, ARID1A (AT-rich Interaction Domain 1 a), appeared ...
Debashish U Menon, Prabuddha Chakraborty, Noel Murcia, Terry Magnuson   +3 more
doaj   +2 more sources

1p36 deletion syndrome: Review and mapping with further characterization of the phenotype, a new cohort of 86 patients

American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 445-458, February 2023., 2023
Abstract Chromosome 1p36 deletion syndrome (1p36DS) is one of the most common terminal deletion syndromes (incidence between 1/5000 and 1/10,000 live births in the American population), due to a heterozygous deletion of part of the short arm of chromosome 1.
Clémence Jacquin, Emilie Landais, Céline Poirsier, Alexandra Afenjar, Ahmad Akhavi, Nathalie Bednarek, Caroline Bénech, Adeline Bonnard, Damien Bosquet, Lydie Burglen, Patrick Callier, Sandra Chantot‐Bastaraud, Christine Coubes, Charles Coutton, Bruno Delobel, Margaux Descharmes, Jean‐Michel Dupont, Vincent Gatinois, Nicolas Gruchy, Sarah Guterman, Abdelkader Heddar, Lucas Herissant, Delphine Heron, Bertrand Isidor, Pauline Jaeger, Guillaume Jouret, Boris Keren, Paul Kuentz, Cedric Le Caignec, Jonathan Levy, Nathalie Lopez, Zoe Manssens, Dominique Martin‐Coignard, Isabelle Marey, Cyril Mignot, Chantal Missirian, Céline Pebrel‐Richard, Lucile Pinson, Jacques Puechberty, Sylvia Redon, Damien Sanlaville, Marta Spodenkiewicz, Anne‐Claude Tabet, Alain Verloes, Gaelle Vieville, Catherine Yardin, François Vialard, Martine Doco‐Fenzy   +47 more
wiley   +1 more source

Enhanced chromatin accessibility of the dosage compensated Drosophila male X-chromosome requires the CLAMP zinc finger protein. [PDF]

PLoS ONE, 2017
The essential process of dosage compensation is required to equalize gene expression of X-chromosome genes between males (XY) and females (XX). In Drosophila, the conserved Male-specific lethal (MSL) histone acetyltransferase complex mediates dosage ...
Jennifer Urban, Guray Kuzu, Sarah Bowman, Benjamin Scruggs, Telmo Henriques, Robert Kingston, Karen Adelman, Michael Tolstorukov, Erica Larschan   +8 more
doaj   +1 more source

Sex Trouble: Common pitfalls in incorporating sex/gender in medical machine learning and how to avoid them [PDF]

, 2022
False assumptions about sex and gender are deeply embedded in the medical system, including that they are binary, static, and concordant. Machine learning researchers must understand the nature of these assumptions in order to avoid perpetuating them. In this perspectives piece, we identify three common mistakes that researchers make when dealing with ...
arxiv   +1 more source

SEX CHROMATIN [PDF]

Journal of Medical Genetics, 1964
Publisher Summary The term “sex chromatin,― denotes a body in the nuclei of cells, which shows a special relationship to the sex of the organism from which the cell originated. The sex-chromatin body is present in the nucleus only during interphase and disappears during mitosis.
openaire   +3 more sources

Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus

The Anatomical Record, Volume 306, Issue 1, Page 162-175, January 2023., 2023
Abstract An adverse maternal environment (AME) and Western diet (WD) in early life predispose offspring toward cognitive impairment in humans and mice. Cognitive impairment associates with hippocampal dysfunction. An important regulator of hippocampal function is the hippocampal Nociceptin/Orphanin FQ (N/OFQ) system. Previous studies find links between
Xingrao Ke, Yingliu Huang, Qi Fu, Amber Majnik, Venkatesh Sampath, Robert H. Lane   +5 more
wiley   +1 more source

The Effect of Sex Chromatin on Some Reproductive Traits of local Sheep in Erbil

مجلة مركز بحوث التقنيات الاحيائية, 2015
This study was conducted on local sheep belongs to private flock in Erbil plain during the period 4 /11/2011 till 25/10/2012. The investigation included 65 local sheep to study the effect of sex chromatin frequency on the Daily Milk Yield (DMY), weight ...
Nihad Ahmad Ameen Ameen, Salim Omar Raoof Raoof   +1 more
doaj   +1 more source