Results 251 to 260 of about 1,768,588 (357)

Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions. [PDF]

Nat Commun
Zhang Z, Li W, Zhan Q, Aillaud M, Botey-Bataller J, Zoodsma M, Ter Horst R, Joosten LAB, Bock C, Schulte LN, Xu CJ, Netea MG, Bonder MJ, Li Y.   +13 more
europepmc   +1 more source

Age‐Dependent Histone Deacetylase 3 Regulation by βA3/A1‐Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age‐Related Macular Degeneration

Aging Cell, EarlyView.
βA3/A1‐crystallin regulates HDAC3 activity and epigenetic processes in the RPE. (A) The illustration demonstrates that βA3/A1‐crystallin plays a crucial role in maintaining IPMK protein expression, which in turn activates HDAC3. (B) When βA3/A1‐crystallin is absent (Cryba1 KO ), IPMK protein expression decreases, resulting in the deactivation of HDAC3.
Sujan Chatterjee, Sayan Ghosh, Zachary Sin, Vishnu Suresh Babu, Loretta Viera Preval, Emily Davis, Nguyen Tran, Sridhar Bammidi, Pooja Gautam, Stacey Hose, Yuri Sergeev, Miguel Flores‐Bellver, Kevin Ritter, Henning J. Jessen, Issam Al Diri, Debasish Sinha, Prasun Guha   +16 more
wiley   +1 more source

The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo [PDF]

Zexiong Lin, Dongliang Li, Jiahuan Zheng, Chencheng Yao, Dongteng Liu, Hao Zhang, Haiwei Feng, Chunxu Chen, Peng Li, Yuxiang Zhang, Binjie Jiang, Zhe Hu, Yu Zhao, Fu Shi, Dandan Cao, Kenny A. Rodriguez‐Wallberg, Zheng Li, William S.B. Yeung, Louise T. Chow, Hengbin Wang, Kui Liu   +20 more
openalex   +1 more source

Editorial: Recent advances in understanding sex-based tumor diversity. [PDF]

Front Pharmacol
Kushwaha S, Kushwaha R, Kushwaha PP.
europepmc   +1 more source

Smoking Promotes AT2 Cell Senescence and Exacerbates Pulmonary Fibrosis by Downregulating POT1 via Integratively Inducing CpG Methylation and MECP2‐Mediated FOXP2 Transcriptional Binding Inhibition

Aging Cell, EarlyView.
Smoking is one of the major causes of pulmonary fibrosis (PF), and treatment options for PF are limited. We show that POT1 is decreased in PF patients and mice, especially in smoke exposure, and investigate its contributions to PF progression from protecting AT2 cell senescence to fibrosis. AAV9‐mediated restoration of POT1 prevents PF.
Mengkun Shi, Wei Wang, Posum Wan, Jialun Shi, Huixia Cui, Zhonghan Sun, Xiaofeng Chen, Jingyu Chen, Jiucun Wang, Xiangguang Shi   +9 more
wiley   +1 more source

Improved epigenetic age prediction models by combining sex chromosome and autosomal markers. [PDF]

Epigenetics Chromatin
Wan Z, Henneman P, Hoefsloot HCJ, Kloosterman AD, Verschure PJ.   +4 more
europepmc   +1 more source

BLOC1S1 Control of Vacuolar Organelle Fidelity Modulates Murine TH2 Cell Immunity and Allergy Susceptibility

Allergy, EarlyView.
Abbreviations: BLOC1S1, biogenesis of lysosome organelles complex 1 subunit 1; cGAS, cyclic GMP‐AMP synthase; GATA3, GATA binding protein 3; IgE, immunoglobulin E; IKK, inhibitor of nuclear factor kappa‐B kinase; IL, interleukin; mtDNA, mitochondrial DNA; NF‐κB, nuclear factor‐kappa B; OVA, ovalbumin; MC903, vitamin D3 analog; STING, stimulator of ...
Rahul Sharma, Kaiyuan Wu, Kim Han, Anna Chiara Russo, Pradeep K. Dagur, Christian A. Combs, Xianglan Yao, Stewart J. Levine, Michael N. Sack   +8 more
wiley   +1 more source

Large-scale genome-wide analyses of stuttering. [PDF]

Nat Genet
Polikowsky HG, Scartozzi AC, Shaw DM, Pruett DG, Chen HH, Petty LE, Petty AS, Lowther EJ, Cho SH, Yu Y, 23andMe Research Team, Mozaffari S, Avery CL, Harris KM, Gordon RL, Beilby JM, Viljoen KZ, Jones RM, Huff CD, Highland HM, Kraft SJ, Below JE.   +21 more
europepmc   +1 more source

Gene–Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies

Allergy, EarlyView.
Atopic eczema is a complex trait resulting from multiple genetic and environmental factors. This study investigated evidence for interaction between 24 established eczema genetic risk variants and 18 environmental factors. One variant‐environmental pair showed nominally significant interaction in discovery, replication and meta‐analyses: early‐life dog
Marie Standl, Ashley Budu‐Aggrey, Luke J. Johnston, Martina S. Elias, S. Hasan Arshad, Peter Bager, Veronique Bataille, Helena Blakeway, Klaus Bønnelykke, Dorret Boomsma, Ben M. Brumpton, Mariona Bustamante Pineda, Archie Campbell, John A. Curtin, Anders Eliasen, João P. S. Fadista, Bjarke Feenstra, Trine Gerner, Carolina Medina‐Gomez, Sarah Grosche, Kristine B. Gutzkow, Anne‐Sofie Halling, Caroline Hayward, John Henderson, Esther Herrera‐Luis, John W. Holloway, Joukejan Hottenga, Jonathan O’B Hourihane, Chen Hu, Kristian Hveem, Amaia Irizar, Bénédicte Jacquemin, Leon Jessen, Sara Kress, Ramesh J. Kurukulaaratchy, Susanne Lau, Sabrina Llop, Mari Løset, Ingo Marenholz, Dan Mason, Daniel L. McCartney, Mads Melbye, Erik Melén, Camelia Minica, Clare S. Murray, Tamar Nijsten, Luba M. Pardo, Suzanne Pasmans, Craig E. Pennell, Maria R. Rinnov, Gillian Santorelli, Tamara Schikowski, Darina Sheehan, Angela Simpson, Cilla Söderhäll, Laurent F. Thomas, Jacob P. Thyssen, Maties Torrent, Toos van Beijsterveldt, Alessia Visconti, Judith M. Vonk, Carol A. Wang, Cheng‐Jian Xu, Ali H. Ziyab, UK Translational Research Network in Dermatology, BIOMAP Consortium, Adnan Custovic, Paola Di Meglio, Liesbeth Duijts, Carsten Flohr, Alan D. Irvine, Gerard H. Koppelman, Young‐Ae Lee, Nick J. Reynolds, Catherine Smith, Sinéad M. Langan, Lavinia Paternoster, Sara J. Brown   +77 more
wiley   +1 more source

ASXL2 Modulates Chromatin Remodeling to Direct Osteogenesis and Multiple Cell Fate in hPDLSCs. [PDF]

Int Dent J
Yang T, Zhou Y, Han R, Hu M, Zeng B, Shi H, Liu D.   +6 more
europepmc   +1 more source