Results 31 to 40 of about 60,046 (266)
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source
Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.
PLoS Genetics, 2023 The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid ...
Ana Catalán +3 more
doaj +1 more source
Glia, Volume 71, Issue 2, Page 377-390, February 2023., 2023 Main Points Aging‐related morphological changes in microglia (dystrophy) do not correlate with expression of universal senescence markers. Microglial dystrophy coincides with an aging‐related increase in microglial ferritin expression. Abstract Aging can cause morphological transformation in human microglia indicative of cell senescence, termed ...
Pauline Neumann +3 more
wiley +1 more source
Chromosome Compaction and Chromatin Stiffness Enhance Diffusive Loop Extrusion by Slip-Link Proteins [PDF]
Soft Matter, 2020,16, 2406-2414, 2019 We use Brownian dynamics simulations to study the formation of chromatin loops through diffusive sliding of slip-link-like proteins, mimicking the behaviour of cohesin molecules. We recently proposed that diffusive sliding is sufficient to explain the extrusion of chromatin loops of hundreds of kilo-base-pairs (kbp), which may then be stabilised by ...
arxiv +1 more source
Epigenetics & Chromatin, 2023 Background Sex determination and differentiation are complex and delicate processes. In female chickens, the process of sex differentiation is sensitive and prone to be affected by the administration of aromatase inhibitors, which result in chicken sex ...
Xiuan Zhang +8 more
doaj +1 more source
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Quantifying the mobility of chromatin during embryogenesis: Nuclear size matters [PDF]
arXiv, 2021 Chromatin moves dynamically inside the cell nucleus, and its motion is often correlated with gene functions such as DNA recombination and transcription. A recent study has shown that during early embryogenesis of the nematode, Caenorhabiditis elegans, the chromatin motion markedly decreases. However, the underlying mechanism for this transition has yet
arxiv
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Essential role of long non-coding RNAs in de novo chromatin modifications: The genomic address code hypothesis [PDF]
Biophysical Reviews Vol. 9, pp. 73-77 (2017), 2017 The epigenome, i.e. the whole of chromatin modifications, is transferred from mother to daughter cells during cell differentiation. When de novo chromatin modifications (establishment or erasure of, respectively, new or pre-existing DNA methylations and/or histone modifications) are made in a daughter cell, however, it has a different epigenome than ...
arxiv +1 more source
Sex Chromatin and Nuclear Sexing in Birds
CYTOLOGIA, 1970 The present study deals with the incidence and distribution of sex chromatin body, drumstick and sessile bodies in two pairs, each of Gallus domesticus, Columba livia and Passer domesticus. Somatic tissues, i.e. liver, duodenum, skin and blood from both sexes were examined.
Chaman Lal Arora +2 more
openaire +4 more sources