Results 91 to 100 of about 3,243,207 (303)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Climbing up the conserved sex determination cascade in tephritidae and mosquitoes.

, 2011
Sex determination cascade studies in tephritidae and ...
SALVEMINI, MARCO, D'AMATO, ROCCO, PETRELLA, VALERIA, SACCONE, GIUSEPPE, Leo S, POLITO, CATELLO   +5 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Role of the Y chromosome in the Ceratitis capitata sex determination and reproduction.

, 2012
Sex determination in early embryos of ...
SALVEMINI, MARCO, D'AMATO, ROCCO, PETRELLA, VALERIA, Dallai R, Ciolfi S, SACCONE, GIUSEPPE, Marchini D, Nagaraju J, Tomar A, POLITO, CATELLO, Franz G   +10 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Comparative population transcriptomics to uncover sex determination of Aedes albopictus and Phlebotomus perniciosus, two emerging hematophagous species

, 2013
Ho presentato il progetto STAR SEXDETSEQ recentemente finanziato durante l'evento dal titolo "Coltiviamo il Futuro", giornata dedicata ai giovani ricercatori organizzata dall’Università Federico II.
SALVEMINI, MARCO
core  

Identification of sex-determination regions and development of male-specific markers for topmouth culter (Culter alburnus)

Aquaculture Reports
The topmouth culter (Culter alburnus), a carnivorous freshwater species in the family Cyprinidae (order Cypriniformes), holds high economic value and displays marked sexual dimorphism in growth, where females exhibit accelerated growth relative to males.
Hong Zhang, Jiayi Yang, Yuhua Tang, Li Hu, Wenting Rao, Xiya Fang, Saibin Gong, Jie Li, Quan Shen, Min Tao, Ming Wen, Shaojun Liu   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source