Results 131 to 140 of about 314,234 (309)

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Evidence for Variation in the Genetic Basis of Sex Determination in Brook Stickleback (Culaea inconstans)

Ecology and Evolution
The genetic basis of sex determination is typically conserved within species if not within broader lineages. For example, within the stickleback family (Gasterosteidae), AmhY has been identified as a master sex‐determination (MSD) gene in multiple ...
Grace C. Pigott, Massa Abo Akel, Malcolm G. Q. Rogers, Marin E. Flanagan, Erica G. Marlette, Matthew J. Treaster, Shannon K. Fox, Shaugnessy R. McCann, Catherine L. Peichel, Michael A. White, Daniel L. Jeffries, Jonathan A. Mee   +11 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Bioinformatics and transcriptomics to uncover the sex determination in the sand fly species Phlebotomus perniciosus, a major Old World vector of Leishmania infantum.

, 2015
In the Old World, the sand fly Phlebotomus perniciosus is the main vector of Leishmania infantum, the parasitic protozoan that causes visceral and cutaneous leishmaniases in humans and canine reservoir host, as well as, of known and emerging arboviruses ...
PETRELLA, VALERIA, SALVEMINI, MARCO, Volf, P., ACETO, SERENA, Robinson, M., Sanges, R., Cicotti, G., Colonna, V., Benes, V., Perrini, S.   +9 more
core  

Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more

Biology of Sex Differences
Background Previous research on Four Core Genotypes and XY* mice has been instrumental in establishing important effects of sex-chromosome complement that cause sex differences in physiology and disease.
Arthur P. Arnold, Xuqi Chen, Michael N. Grzybowski, Janelle M. Ryan, Dale R. Sengelaub, Tara Mohanroy, V. Andree Furlan, Helen R. Schmidtke, Jeremy W. Prokop, Monika Tutaj, Julia L. Ciosek, Theodore S. Kalbfleisch, Liza O’Donnell, William Grisham, Shanie Landen, Lynn Malloy, Akiko Takizawa, Kai Li, Hayk Barseghyan, Carrie B. Wiese, Laurent Vergnes, Karen Reue, Jonathan Wanagat, Helen Skaletsky, David C. Page, Vincent R. Harley, Melinda R. Dwinell, Aron M. Geurts   +27 more
doaj   +1 more source

Use of Lateral Teleradiography in Sex Estimation for Forensic Purposes: a Systematic Review

Acta Stomatologica Croatica
Methods that use lateral teleradiography for sex estimation need to be discussed considering their feasibility and applicability in forensic cases. Purpose: The aim of this study was to conduct a systematic review about the use of lateral teleradiography
Isabela Dos Santos Moreira, Ana Elisa Martins Parreira Chaves, Paulo Henrique Viana Pinto, Ricardo Henrique Alves Da Silva   +3 more
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits

, 2002
We tested the hypothesis that genes encoded on the sex chromosomes play a direct role in sexual differentiation of brain and behavior. We used mice in which the testis-determining gene (Sry) was moved from the Y chromosome to an autosome (by deletion of ...
Robin Lovell-Badge, De Vries, Geert, Auger, CJ, Lovell-Badge, R, Catherine J. Auger, Elka M. Scordalakes, Swain, A, Simerly, Richard B., Lovell-Badge, Robin, Richard B. Simerly, Amanda Swain, Arnold, Arthur P., Simerly, RB, Burgoyne, PS, Scordalakes, Elka M., Emilie F. Rissman, Geert J. De Vries, Liang-Yo Yang, Burgoyne, Paul S., Yang, Liang-Yo, Yang, L-Y, Rissman, EF, Rissman, Emilie F., Paul S. Burgoyne, De Vries, G, Arnold, AP, Arthur P. Arnold, Scordalakes, EM, Swain, Amanda, Auger, Catherine J.   +29 more
core   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source