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Sex determination and sex reversal
Current Opinion in Genetics & Development, 2006Sex determination in mammals is based on a genetic cascade that controls the fate of the gonads. Gonads will then direct the establishment of phenotypic sex through the production of hormones. Different types of sex reversal are expected to occur if mutations disrupt one of the three steps of gonadal differentiation: formation of the gonadal primordia,
G. Camerino +3 more
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Trends in Endocrinology & Metabolism, 1997
Recently, a number of genes have been identified that are associated with a failure of human sex determination, including WT1, DAX-1, SOX9, ATRX, and the Y-linked testis determination gene, SRY. Most cases of human sex reversal, XY females and XX males, do not, however, appear to be caused by mutations in these genes.
K, McElreavey, M, Fellous
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Recently, a number of genes have been identified that are associated with a failure of human sex determination, including WT1, DAX-1, SOX9, ATRX, and the Y-linked testis determination gene, SRY. Most cases of human sex reversal, XY females and XX males, do not, however, appear to be caused by mutations in these genes.
K, McElreavey, M, Fellous
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American Journal of Obstetrics and Gynecology, 1972
Abstract Prenatal sex was diagnosed by the sex chromatin and the Y fluorescent body techniques simultaneously applied to uncultured amniotic fluid cells obtained by amniocentesis in 111 cases during the second trimester of pregnancy and in 6 cases at term.
C, Valenti +4 more
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Abstract Prenatal sex was diagnosed by the sex chromatin and the Y fluorescent body techniques simultaneously applied to uncultured amniotic fluid cells obtained by amniocentesis in 111 cases during the second trimester of pregnancy and in 6 cases at term.
C, Valenti +4 more
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Human Molecular Genetics, 1994
The cloning of the 'testis determining gene', SRY, promised a revolution in the understanding of sex determination in humans. The failure to isolate further genes involved in sex determination has been a disappointment. The biology of SRY, however, has kept the field exciting. The discoveries of sex reversing SRY mutations with variable penetrance, but
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The cloning of the 'testis determining gene', SRY, promised a revolution in the understanding of sex determination in humans. The failure to isolate further genes involved in sex determination has been a disappointment. The biology of SRY, however, has kept the field exciting. The discoveries of sex reversing SRY mutations with variable penetrance, but
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Forensic Science, Medicine and Pathology, 2006
Determing the sex of a give DNA sample can provide criminal investigators with useful intelligence and can aid the identification of missing persons and disaster victims. Polymerase chain reaction-based systems that amplify regions of the am elogenin gene have become the method of choice for sex determination of biological samples.
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Determing the sex of a give DNA sample can provide criminal investigators with useful intelligence and can aid the identification of missing persons and disaster victims. Polymerase chain reaction-based systems that amplify regions of the am elogenin gene have become the method of choice for sex determination of biological samples.
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Sex Determination: Turning on sex
Current Biology, 1994The orphan nuclear receptor, steroidogenic factor 1, is central to the differentiation of male and female mammalian gonads. It controls the fate of the initially bipotential gonad as well as later male-specific functions.
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Science, 2017
Females actively eliminate male reproductive ducts during mammalian ...
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Females actively eliminate male reproductive ducts during mammalian ...
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Amphibian sex determination and sex reversal
Cellular and Molecular Life Sciences, 1999Amphibians employ a genetic mechanism of sex determination, according to all available information on sex chromosomes or breeding tests. Sex reversal allows breeding tests to establish which sex is heterogametic and provides an indication of the mechanism of sex determination. Cases of spontaneous and experimental sex reversal (by temperature, hormones
H, Wallace, G M, Badawy, B M, Wallace
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