Results 31 to 40 of about 1,758,122 (189)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Diversity and the Undertreatment of Pain [PDF]

, 2002
The undertreatment of pain is a major public health problem and has enormous costs -- to the individual, the health care system and society. Undertreatment is complex and many studies have clarified the factors that may contribute.
Terry Altilio
core  

Risk Factors for Long-Term Coronary Artery Calcium Progression in the Multi-Ethnic Study of Atherosclerosis. [PDF]

, 2015
BackgroundCoronary artery calcium (CAC) detected by noncontrast cardiac computed tomography scanning is a measure of coronary atherosclerosis burden. Increasing CAC levels have been strongly associated with increased coronary events.
Blaha, Michael J, Budoff, Matthew, Gassett, Amanda J, Kaufman, Joel D, Kronmal, Richard, McClelland, Robyn L, Olives, Casey, Sheppard, Lianne   +7 more
core   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

'It is like a tomato stall where someone can pick what he likes': structure and practices of female sex work in Kampala, Uganda. [PDF]

, 2013
BACKGROUND: Effective interventions among female sex workers require a thorough knowledge of the context of local sex industries. We explore the organisation of female sex work in a low socio-economic setting in Kampala, Uganda.
A-M Cote, AH Norris, C Harcourt, D Whittaker, F Scorgie, F Van den Borne, G Asiki, I Vanwesenbeeck, IB Zablotska, J Bukenya, J Nazziwa, J Seeley, J Vandepitte, J Vandepitte, JAA Munoz, Janet Seeley, JP Ntozi, Judith Vandepitte, K Fritz, L Van Blerk, M Gysels, M Mbonye, Martin Mbonye, ML Rekart, NTT Thuy, PM Pyett, QA Karim, Rachel King, S Baral, S Jana, Sarah Nakamanya, SC Kalichman, SE Woolf-King, UNAIDS, Winifred Nalukenge   +34 more
core   +2 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Children of same-sex couples in the United Kingdom [PDF]

, 2008
To further develop an understanding of psychological and social functioning of children raised by lesbian couples, the current investigation compared 18 students ages 12 through 16 raised in families led by female same-sex couples who were identified ...
Noret, N, Poteat, V P, Rivers, I
core  

Sex Ratio and Sexual Dimorphism in \u3ci\u3eFormica Exsectoides\u3c/i\u3e, the Allegheny Mound Ant (Hymenoptera: Formicidae) [PDF]

, 2018
We excavated 66 mounds from 6 populations of Formica exsectoides in Michigan jack pine, collecting sexual caste pupae for sex ratio estimates and measurement of dimorphism.
Bristow, C. M, Rowe, H. C
core   +2 more sources

Sex-Specific Factors in Microvascular Angina [PDF]

Canadian Journal of Cardiology, 2014
In women presenting for evaluation of suspected ischemic symptoms, a diagnosis of normal coronary arteries is 5 times more common than it is in men. These women are often labelled as having cardiac syndrome X, and a subset of them have microvascular angina caused by microvascular coronary dysfunction (MCD).
Tara Sedlak, Tara Sedlak, Karin H. Humphries, Karin H. Humphries, Mona Izadnegahdar, C. Noel Bairey Merz   +5 more
openaire   +3 more sources