Results 271 to 280 of about 60,867 (320)
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Sex hormone-binding globulin and female reproductive function
The Journal of Steroid Biochemistry and Molecular Biology, 1995Although sex steroids have long been known to influence serum concentrations of SHBG, it is now recognized that nutritional factors may be more important in the regulation of SHBG in women. Thus, SHBG concentrations are negatively correlated with body mass index (BMI) and, more particularly, to indices of central adiposity.
N, Botwood +4 more
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Evaluation of automated sex hormone binding globulin immunoassays
Clinical Biochemistry, 2006Sex hormone binding globulin (SHBG) is an important regulator of testosterone and estradiol.We validated the Diagnostic Products Corporation (DPC) and Roche Diagnostic SHBG immunoassays on the DPC Immulite 2000 and Roche Modular E170 analyzers.The coefficient of variation for SHBG kits from both manufacturers was in the range of 3.9-7.7% (between-run ...
Ming, Jin +2 more
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Sex hormone-binding globulin in congenital adrenal hyperplasia
hmbci, 2009Abstract Background: Sex hormone-binding globulin biosynthesis is influenced by three hormonal systems: gonadal, insular and thyroid. Congenital adrenal hyperplasia is characterized by overproduction of adrenal androgens associated with impaired insulin sensitivity, hyperinsulinemia and often also with hypothyroidism ...
Ludmila, Zamrazilová +4 more
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Free estradiol and sex hormone-binding globulin
Steroids, 2015SHBG is a plasma protein that participates in the regulation of free estradiol and free testosterone in plasma. We discuss the concept of the nature of a free estradiol and how best to ascertain its value. It can be measured or calculated; the ways in which this can be done are explored along with the advantages and disadvantages of each.
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Sex-Hormone-Binding Globulin is an Oestrogen Amplifier
Nature, 1972WE suggest a novel biological role for a specific plasma-binding protein in the regulation of oestrogen and androgen activity in man. The biological activity of oestradiol and testosterone, as with other steroids1, is probably exerted by the unbound fraction in plasma; this is only 1–3% of the total concentration.
C W, Burke, D C, Anderson
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Clinical Utility of Sex Hormone-Binding Globulin Measurement
Hormone Research, 1996The high-affinity binding of the sex hormone-binding globulin (SHBG) for testosterone and to a lesser extent for estradiol influences the circulating levels of these sex steroid hormones, their biodisposal to target cells as well as their mutual balance. Although the regulation of SHBG is still not completely understood, in vitro studies performed with
M, Pugeat +3 more
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Sex Hormone-Binding Globulin Changes with Androgen Replacement
The Journal of Clinical Endocrinology & Metabolism, 1983Since sex hormone-binding globulin (SHBG) levels are often elevated in sera of patients with testicular insufficiency, it is important to determine whether SHBG declines into the normal range and the extent of change in free testosterone (free T) after androgen administration.
S R, Plymate +4 more
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Sex hormone-binding globulin and male sexual development
Neuroscience & Biobehavioral Reviews, 1995The masculinization of the brain, reproductive tract and many other structures is critically dependent on the testicular hormone, testosterone (T). In many species, T circulates bound with high affinity to sex hormone-binding globulin (SHBG). This protein has a wide phylogenetic distribution and SHBG or SHBG-like proteins are produced by the liver ...
D A, Damassa, J M, Cates
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Are Corticosteroid‐Binding Globulin and Sex Hormone‐Binding Globulin Hormones?a
Annals of the New York Academy of Sciences, 1988Because it no longer seemed reasonable to us that the sole function of the steroid-binding proteins in plasma was to serve as a buffer reservoir for steroid hormones, we conducted experiments which sought out other possibilities. Both CBG and SHBG bind to cell membranes, and this interaction partakes of the general characteristics of peptide hormone ...
W, Rosner +4 more
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