Results 131 to 140 of about 3,349,682 (373)

Self‐Powered α Radionuclide Nanomedicine: Mitochondria‐Targeted Multimodal Energy Recycling for Amplified Radioimmunotherapy

open access: yesAdvanced Materials, EarlyView.
A multifunctional nanomedicine co‐loading of the α‐emitter 223RaCl2 within iron‐based MOFs is developed. Precisely targeted to mitochondria, it exploits the full decay spectrum to synchronize three therapeutic actions: direct α‐particle ionization, self‐powered catalytic H2O2 generation via secondary electrons, and immunogenic cell death induction ...
Xian Li   +7 more
wiley   +1 more source

A Woman’s Worth [PDF]

open access: yes, 2010
This Article examines three traditionally “taboo trades”: (1) the sale of sex, (2) compensated egg donation, and (3) commercial surrogacy. The Article purposely invokes examples in which the compensated provision of goods or services (primarily or ...
Krawiec, Kimberly D.
core   +1 more source

Reliable Sex and Strain Discrimination in the Mouse Vomeronasal Organ and Accessory Olfactory Bulb

open access: yesJournal of Neuroscience, 2013
Animals modulate their courtship and territorial behaviors in response to olfactory cues produced by other animals. In rodents, detecting these cues is the primary role of the accessory olfactory system (AOS).
I. Tolokh, Xiaoyan Fu, T. Holy
semanticscholar   +1 more source

High‐Entropy Materials for Water Splitting: An Atomic Nanoengineering Approach to Sustainable Hydrogen Production

open access: yesAdvanced Materials, EarlyView.
High‐entropy materials (HEMs), typically composed of five or more principal elements in near‐equimolar ratios, offer significant potential due to their unique properties. This review outlines the emergence and structural evolution of HEMs, followed by an in‐depth discussion of the elemental roles (active sites, promoters, or stabilizers) for water ...
Yufei Zhao   +9 more
wiley   +1 more source

Biobased Ligands Enable Catalysis with Base Metals

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Biobased ligands unlock versatile catalytic transformations, including Cu‐catalyzed hydroboration of olefins and borylation of alkyl halides, Fe‐catalyzed ketone hydrogenation, and Ni‐catalyzed terminal alkyne dimerization. First‐row transition metal catalysis has already reshaped organic synthesis, offering more abundant and cost‐effective ...
Raju Yalla, Ashot Gevorgyan
wiley   +1 more source

Non‐Invasive Diagnosis of Chronic Myocardial Infarction via Composite In‐Silico‐Human Data Learning

open access: yesAdvanced Science, EarlyView.
This study presents a non‐invasive machine learning model to identify infarct regions in the left ventricle using cardiac strain data. By combining rodent‐based simulated data with limited human data, the model achieves high accuracy in predicting infarct size and location without the need for gadolinium contrast agents, offering a promising ...
Rana Raza Mehdi   +7 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

open access: yesAdvanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu   +13 more
wiley   +1 more source

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