Results 151 to 160 of about 460,515 (259)

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Sex differences in baroreflex sensitivity, heart rate variability, and end organ damage in the TGR(mRen2)27 rat

, 2011
Megan S. Johnson, Vincent G. DeMarco, Cheryl M. Heesch, Adam Whaley‐Connell, Rebecca I. Schneider, Nathan Rehmer, Roger D. Tilmon, Carlos M. Ferrario, James R. Sowers   +8 more
openalex   +2 more sources

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Socioeconomic distribution of cancer of the female sex organs in new haven [PDF]

, 1955
Edward M. Cohart
openalex   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Sex dependent alteration of epigenetic marks after chronic morphine treatment in mice organs

, 2021
Iraia Muñoa-Hoyos, Manu Araolaza, Itziar Urizar‐Arenaza, Marta Gianzo Citores, Jon Irazusta, Nerea Subirán   +5 more
openalex   +1 more source

An Analysis by the European Committee on Organ Transplantation of the Council of Europe Outlining the International Landscape of Donors and Recipients Sex in Solid Organ Transplantation [PDF]

, 2022
Emanuele Cozzi, Marina Álvarez Benito, Mar Carmona, Beatriz Mahíllo, John Forsythe, Mar Lomero, Marta López‐Fraga, Ruth Sapir‐Pichhadze, Massimo Cardillo, Beatriz Domínguez‐Gil   +9 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Effect of Iron Overload on Gonadotrophins and Organ Sex Steroids in Pubertal Thalassemia Patients

, 2017
Manali Sinharay, Surabhi Mitra, Anindya Dasgupta, M Bashyam, L Bashyam, G Savithri, A Gupta, Y Hattori, U Gupta, R Mariani, P Trombini, M Pozzi, Prabhu Taksandea, S Venkatesh, M Cappellini, De Sanctis, V Soliman, A Elsedfy, H Skordis, N Kattamis, C, A Taher, J Porter, V Viprakasit, A Kattamis, S Chuncharunee, P Sutcharitchan, G Raiola, M Galati, De Sanctis, V, Caruso Nicoletti, M Pintor, C, De Simone, M, Aa Shamshirsaz, A Masala, T Meloni, D Gallisai, S Alagna, P Rovasio, S Rassu, A Milia, A Zervas, A Katopodi, A Protonotariou, S Livadas, M Karagiorga, C Politis, G Tolis, O Sasima, Boonsong, P Walter, E Fung, D Killilea, Q Jiang, M Hudes, J Madden, J Porter, P Evans, E Vichinsky, P Harmatz, R Chatterjee, M Katz, Ellen Fung, J Chern, K Lin, W Tsai, S Wang, M Lu, D Lin, M Delvecchio, L Cavallo, N Bronspiegel-Weintrob, N Olivieri, B Tyler, D Andrews, Sinharay, S Atkin, L Hipkin, A Landolt, R Jeffreys, P Foy, M White, V Canale, P Steinherz, M New, M Erlandson, Rifki, Erdal, O Murat, Sehmus, D Murat, B Yaren, Aydin, B Modell, M Khan, M Darlison, M Westwood   +99 more
openalex   +1 more source

Sex Differences in Mortality Based on United Network for Organ Sharing Status While Awaiting Heart Transplantation [PDF]

, 2017
Eileen Hsich, Eugene H. Blackstone, Lucy Thuita, Dennis M. McNamara, Joseph G. Rogers, Hemant Ishwaran, Jesse D. Schold   +6 more
openalex   +1 more source