Results 291 to 300 of about 3,431,915 (390)

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, EarlyView.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

Knowledge and attitudes of university staff toward organ donation: a cross-sectional study in Oman. [PDF]

PeerJ
Alwahaibi N, Al Ghawi S, Al-Badi M.
europepmc   +1 more source

Cheap Sentiment [PDF]

, 2018
Hill, Claire A.
core   +2 more sources

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, EarlyView.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Relationships among dietary patterns and heterogeneous biological aging at system and organ-specific levels and mortality risks. [PDF]

NPJ Sci Food
Xu X, Li Y, Wang Y, Song BR, Zhan J, Zong G, Chen X, Xu K, Sun L, Feng C, Lichtenstein AH, Gao X.   +11 more
europepmc   +1 more source

Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing

Advanced Science, EarlyView.
Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley   +1 more source

Implications of a New Obesity Definition Among the All of Us Cohort.

JAMA Netw Open
Fourman LT, Awwad A, Gutiérrez-Sacristán A, Dash CA, Johnson JE, Thistle AK, Chahal N, Stockman SL, Toribio M, Anekwe C, Gattu AK, Grinspoon SK.   +11 more
europepmc   +1 more source

Moderate agreement between the spot albumin‒Creatinine ratio (ACR) and urine albumin (UA) among virally suppressed adults living with HIV in botswana: a cross sectional study. [PDF]

AIDS Res Ther
Mosepele M, Ponatshego PL, Molebatsi K, Kebotsamang K, Williams C, Mokgatlhe L, Lockman S, Youssouf N, Gross R, Jarvis J, Moshomo T, Jaffar S, Wang D.   +12 more
europepmc   +1 more source

Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals

Advanced Science, EarlyView.
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai, Patrizia Mazzucato, Catherine Ricciardi, David C. Christiani, Liming Liang, Leona D. Samson, Isaac A. Chaim, Zachary D. Nagel   +7 more
wiley   +1 more source

Incidence, Risk Factors, and Mortality Associated with Tuberculosis in Solid Organ Transplant Recipients in Taiwan. [PDF]

Tuberc Respir Dis (Seoul)
Chuang SY, Tang CF, Lin KH, Lai CH, Yin YT, Tsai MK, Wu MS, Wu MY.   +7 more
europepmc   +1 more source